| Identification | More | [Name]
2-Chloropyrazine | [CAS]
14508-49-7 | [Synonyms]
2-CHLOROPYRAZINE
CHLOROPYRAZINE
CHLOROPYRAZINE, 2-
2-Dichloropyrazine
chloro-pyrazin
Pyrazine, chloro-
CHLOROPYRAZINE, 2-(SG) | [EINECS(EC#)]
238-517-0 | [Molecular Formula]
C4H3ClN2 | [MDL Number]
MFCD00006124 | [Molecular Weight]
114.53 | [MOL File]
14508-49-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to yellowish liquid | [Melting point ]
153～154℃ | [Boiling point ]
153-154 °C (lit.) | [density ]
1.283 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.539(lit.)
| [Fp ]
136 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in Methanol | [form ]
Liquid | [pka]
-1.10±0.10(Predicted) | [color ]
Clear colorless to yellow | [Specific Gravity]
1.283 | [Water Solubility ]
INSOLUBLE | [Detection Methods]
HPLC,NMR | [BRN ]
107019 | [LogP]
0.700 | [CAS DataBase Reference]
14508-49-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Chloropyrazine(14508-49-7) | [EPA Substance Registry System]
14508-49-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29339990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Glyoxal | [Preparation Products]
N-Boc-5,6,7,8-tetrahydro-3-methoxy-[1,2,4]triazolo[4,3-A]pyrazine ,98%-->METHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE-->1-(2-PYRAZINYL)-PIPERAZINE-->3-Chloropyrazine-2-carbonitrile-->3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-->2,3-Dichloropyrazine-->3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-->Pyrazinecarbonitrile-->2-ISOPROPYLPYRAZINE-->2-Methyl-3-(methylthio)pyrazine-->2,2'-Bipyrazine-->Iodopyrazine-->Pyrazine-->2-(Methylthio)pyrazine-->2-Methoxypyrazine-->BENZYL-PYRAZIN-2-YL-AMINE-->Isopropyl-pyrazin-2-yl-aMine-->1-(PYRAZIN-2-YL)-1H-PYRAZOLE-4-CARBALDEHYDE-->2-METHYL-2-PYRAZIN-2-YL-PROPIONITRILE |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to yellowish liquid | [Uses]
Cardiotonic | [Application]
2-Chloropyrazine is used as a reagent in the synthesis of hetaryloxy benzoxaborole compounds which have antimalarial activity. 2-Chloropyrazine is also used to prepare 4,5-disubstituted 6-aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles which are broad-spectrum serine β-lactamase inhibitors. | [Definition]
ChEBI: 2-chloropyrazine is a member of pyrazines. | [Purification Methods]
Fractionally distil it through a short column packed with glass helices. It has apenetrating, mildly pungent odour with a high vapour pressure at room temperature. [Erickson & Spoerri J Am Chem Soc 68 400 1946, Hetman & O.Donnell J Org Chem 28 1682 1963, Beilstein 23/5 V 366.] |
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