| Identification | Back Directory | [Name]
Elacridar HCl | [CAS]
143851-98-3 | [Synonyms]
EOS-62093
Elacridar HC1
Elacridar HCl
Elacridar HCl USP/EP/BP
Elacridar (hydrochloride)
GF 120918A; GF120918A; GF-120918A
N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihy
N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide,hydrochloride
N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamidehydrochloride
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide hydrochloride
N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-4-acridinecarboxamide monohydrochloride
GW 0918
N-[4-[2-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-Methoxy-9-oxo-4-acridinecarboxaMide, (HCl salt)
4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo-, hydrochloride (1:1)
1-{2-carbaMoyl-5-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}-5-Methoxy-9-oxo-9,10-dihydroacridine-4-carboxylic acid hydrochloride | [Molecular Formula]
C34H33N3O5.ClH | [MDL Number]
MFCD11040791 | [MOL File]
143851-98-3.mol | [Molecular Weight]
600.112 |
| Chemical Properties | Back Directory | [Melting point ]
>198oC (dec.) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated) | [form ]
Solid | [color ]
Orange | [Stability:]
Hygroscopic | [CAS DataBase Reference]
143851-98-3 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow powder | [Uses]
Antineoplastic (adjunct). | [in vivo]
Elacridar hydrochloride (100 mg/kg; i.p. once) shows different distribution in brain and plasma[1].
1.19 Plasma Pharmacokinetic Parameters of Elacridar hydrochloride in mice[1]. | Mice
PO 100 mg/kg | Mice
IP 100 mg/kg | Mice
IV 2.5 mg/kg | | CL/F (ml/min) | 2.05 | 33.2 | 0.46 | | Vd/F (liter) | 3.5 | 12.3 | 0.17 | | t1/2 (h) | 20 | 4.3 | 4.4 | | AUC0-inf (μg·min/ml) | 1460 | 90.3 | 161.4 | | F | 0.22 | 0.013 | 1 |
| Animal Model: | FVB wild-type mice[1] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection; 100 mg/kg once | | Result: | Showd a higher concertration in brain than plasma except at 4 h after administration. |
| [storage]
Store at -20°C |
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