| Identification | More | [Name]
D-alpha-Cyclohexylglycine | [CAS]
14328-52-0 | [Synonyms]
2-CYCLOHEXYL-D-GLYCINE
CYCLOHEXYL-D-GLYCINE
D-2-CYCLOHEXYL-GLYCINE
D-2-CYCLOHEXYLGLYCINE TRIFLUOROACETATE
D-ALPHA-CYCLOHEXYLGLYCINE
D-CHG
D-CYCLOHEXYLGLYCINE
H-CYCLOHEXYL-D-GLY-OH
H-CYCLOHEXYL-D-GLY-OH TFA
H-D-CHG-OH
H-D-CHG-OH TFA
H-PHG(HEXAHYDRO)-OH
(R)-(+)-ALPHA-AMINOCYCLOHEXYLACETIC ACID
(R)-ALPHA-AMINOCYCLOHEXYLACETIC ACID
(R)-AMINO-CYCLOHEXYL-ACETIC ACID
(R)-CYCLOHEXYLGLYCINE
H-D-Cyclohexyl-Gly-OH
D-Cyclohexyglycine
(2S)-amino(cyclohexyl)acetic acid
D-CYCLOHEXYLGLYCINE 98% | [Molecular Formula]
C8H15NO2 | [MDL Number]
MFCD02262223 | [Molecular Weight]
157.21 | [MOL File]
14328-52-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
256 °C | [alpha ]
-34.5 º (c=0.4 5N HCl) | [Boiling point ]
292.8±23.0 °C(Predicted) | [density ]
1.120±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
2.44±0.10(Predicted) | [Water Solubility ]
Soluble | [BRN ]
3196806 | [InChIKey]
WAMWSIDTKSNDCU-SSDOTTSWSA-N | [CAS DataBase Reference]
14328-52-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [HS Code ]
29224999 |
| Questions And Answer | Back Directory | [Description]
D-alpha-Cyclohexylglycine is a kind of non-proteinogenic amino acid. It is widely presented in various natural products and pharmaceutical intermediates. It can be incorporated into the peptide inhibitors renders resistance from peptidases and proteinases and thereby imparts pharmacological stability to molecules. Some derivatives of Cyclohexylglycine has been recently been developed into inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes.
| [References]
https://www.qmbio.com/?shopp_category=chg
Edmondson, Scott D., A. Mastracchio, and E. R. Parmee. "CYCLOHEXYLGLYCINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES." (2008).
Mastracchio, Anthony, et al. "Heterocycle-Fused Cyclohexylglycine Derivatives as Novel Dipeptidyl Peptidase-IV Inhibitors. " Cheminform 35.35(2004):203-206.
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