| Identification | More | [Name]
Protionamide | [CAS]
14222-60-7 | [Synonyms]
2-PROPYL-THIOISONICOTINAMIDE
PROTHIONAMIDE
PROTIONAMIDE
1321th
2-propyl-4-pyridinecarbothioamid
2-propyl-4-pyridinecarbothioamide
2-propyl-4-thiocarbamoylpyridine
2-propylisonicotinylthioamide
2-Propylpyridine-4-carbothionamide
2-propylthio-isonicotinamid
9778r.p.
ektebin
peteha
protion
protionamid
protionizina
tebeform
trevintix
tuberex
Prothionamide (BP88)Prothionamide | [EINECS(EC#)]
238-093-7 | [Molecular Formula]
C3H7NO | [MDL Number]
MFCD00464119 | [Molecular Weight]
73.09 | [MOL File]
14222-60-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
140-143°C | [Boiling point ]
310.4±44.0 °C(Predicted) | [density ]
1.1015 (rough estimate) | [refractive index ]
1.5300 (estimate) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12.14±0.29(Predicted) | [color ]
Yellow | [Merck ]
14,7891 | [CAS DataBase Reference]
14222-60-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [RTECS ]
NS0650000 | [HazardClass ]
IRRITANT | [HS Code ]
2933399990 | [Toxicity]
LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in) |
| Hazard Information | Back Directory | [Chemical Properties]
Protionamide is Yellow Solid
| [Uses]
An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic). | [Uses]
Protionamide is an antibacterial used against Mycobacterium tuberculosis bacteria.
| [Definition]
ChEBI: Prothionamide is a member of pyridines. | [Biological Activity]
Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB)prothionamide causes the development of hepatitis. In rare casesit causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by feverhematologic abnormalitiesskin eruptionand internal organ disruption. | [storage]
Store at -20°C |
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