| Identification | Back Directory | [Name]
Azadibenzocyclooctyne-Biotin conjugate | [CAS]
1418217-95-4 | [Synonyms]
DBCO-Biotin
DBCO-(CH2)2-NH2-BIOTIN
Azadibenzocyclooctyne-Biotin conjugate
DBCO-Biotin,Azadibenzocyclooctyne-Biotin conjugate
(3AS,4S,6aR)-N-[3-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-, (3aS,4S,6aR)- | [Molecular Formula]
C28H30N4O3S | [MDL Number]
MFCD22380751 | [MOL File]
1418217-95-4.mol | [Molecular Weight]
502.63 |
| Chemical Properties | Back Directory | [Boiling point ]
905.9±65.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.90±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DBCO-Biotin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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