| Identification | Back Directory | [Name]
DBCO-NHS | [CAS]
1353016-71-3 | [Synonyms]
DBCO-NHS
CAS_1353016-71-3
DBCO-NHS ester
(DBCO NHS ester)
N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate
11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester
Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C23H18N2O5 | [MDL Number]
MFCD24386367 | [MOL File]
1353016-71-3.mol | [Molecular Weight]
402.4 |
| Chemical Properties | Back Directory | [Boiling point ]
670.2±65.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
-0.23±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions. | [Uses]
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging. |
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