| Identification | Back Directory | [Name]
2,6-DIFLUORO-4-[2-(PHENYLSULFONYLAMINO)E | [CAS]
141286-78-4 | [Synonyms]
2-[2,6-Difluoro-4-[[2-[(phenylsulfonyl)amino]ethyl]thio]phenoxy]acetamide
2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide (PEPA) | [Molecular Formula]
C16H16F2N2O4S2 | [MDL Number]
MFCD04974493 | [MOL File]
141286-78-4.mol | [Molecular Weight]
402.44 |
| Hazard Information | Back Directory | [Uses]
PEPA is an allosteric potentiator of AMPA desensitization. | [Biological Activity]
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration. | [Biochem/physiol Actions]
2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats. | [storage]
Store at RT |
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