| Identification | Back Directory | [Name]
Zinc bacitracin | [CAS]
1405-89-6 | [Synonyms]
Albac
Noptracin
Baciferm PB
Bacitracinzink
ZINC BACITRACIN
BACITRACIN ZINC
Bacitracin zine
BACITRACINE ZINC
ZINC BACITRACIN USP
BACITRACIN ZINC SALT
Bacitracin Zinc USP
Zinc Bacitracin(USP35)
BACITRACIN ZINC SALT USP
BACITRACINZINC,MICRONIZED
Bacitracin Zinc (200 mg)
ZIBA-RX (bacitracin zinc)
BACITRACINZINC,MICRONIZED,USP
Methylprednisolone, Micronized
Bacitracin zinc salt,>=70 U/Mg
Polymyxin B Sulfate bacitracin zinc
Bacitracin, zinc saltZinc bacitracin
Bacitracin Zinc salt from Bacillus sp.
Zinc bacitracin
Bacitracin zinc salt
Bacitracin, zinc salt, potency min. 60 Units/mg
bacitracin zinc salt from bacillus licheniformis
BACITRACIN U.S.P. ACTIVITY: 60 UNITS/MG MINIMUM ZINC SALT
4-[2-[[2-(1-AMINO-2-METHYL-BUTYL)-4,5-DIHYDRO-1,3-THIAZOL-4-YL]CARBONYLAMINO]-4-METHYL-PENTANOYL]AMINO-5-[1-[[18-(3-AMINOPROPYL)-12-BENZYL-15-BUTAN-2-YL-3-(CARBAMOYLMETHYL)-6-(CARBOXYMETHYL)-9-(4H-IMIDAZOL-4-YLMETHYL)-2,5,8,11,14,17,20-HEPTAOXO-1,4,7,10,13,16,19-HEPTAZACYCLOPENTACOS-21-YL]CARBAMOYL]-2-METHYL-BUTYL]AMINO-5-OXO-PENTANOIC ACID, ZINC | [EINECS(EC#)]
215-787-8 | [Molecular Formula]
C66H101N17O16SZn | [MDL Number]
MFCD00130598 | [MOL File]
1405-89-6.mol | [Molecular Weight]
1486.07 |
| Chemical Properties | Back Directory | [Appearance]
White to pale buff powder | [Melting point ]
250 °C (dec.) | [storage temp. ]
2-8°C
| [solubility ]
10 mM HCl: 5 mg/mL, clear, faintly yellow-green
| [form ]
Fine Crystalline Powder | [color ]
White to light yellow-gray or beige | [PH]
Shake 1.0 g with 10 mL of carbon-dioxide-free water R and filter; pH of the filtrate, 6.0-7.5. | [Water Solubility ]
5.1 g/L (28 ºC) | [Merck ]
13,938 | [InChIKey]
UCRLQOPRDMGYOA-FWMPYRTHSA-L | [LogP]
-1.852 (est) | [EPA Substance Registry System]
Bacitracin zinc(1405-89-6) |
| Hazard Information | Back Directory | [Chemical Properties]
White to pale buff powder | [Description]
Bacitracin is a cyclic polypeptide antibiotic that was first isolated from B. licheniformis.1 Formulations containing bacitracin, often combined with other antibiotics, are used for topical treatment of infections in humans and animals.2,3 The activity of bacitracin can be enhanced by zinc.4 Bacitracin sequesters C55-isopropyl pyrophosphate (IPP), a lipid carrier in peptidoglycan synthesis, and in this way disrupts cell wall biosynthesis.2,3 | [Indications]
Bacitracin zinc is composed of a group of polypeptides with antibiotic activity against a variety of Gram-positive bacteria including staphylococci. It is used in the treatment of local infections, mainly infections of the skin, ear and eye. | [Brand name]
Ziba
(X Gen). | [storage]
Bacitracin zinc should be kept in a tightly closed container, protected from light, and stored at a temperature not exceeding 25 °C. If it is intended for parenteral administration, the container should be sterile and sealed so as to exclude microorganisms. |
| Questions And Answer | Back Directory | [what is bacitracin zinc used for]
Bacitracin zinc is bacitracin and zinc ions to form complexes, which is a polypeptide antibiotic, is one of the most widely used antibiotics in feed additives, zinc content is 2%~12%. synthetic product is white or yellowish powder, with special odor, deliquescent alkaline substance, soluble in water, methanol and ethanol. Bacitracin zinc has strong antibacterial effect against gram positive bacteria, also has antibacterial properties of some gram negative bacteria. The use of bacitracin zinc in pig feed, can promote growth, improve feed, prevention and treatment of swine bacterial diarrhea and chronic respiratory diseases. The concentration of 10 in general to 100mg/kg, more than the addition range of effect was not improved obviously. Bacitracin zinc in swine intestine is not generally absorbed, so there is no problem, is a reliable and safe antibiotic additives. Bacitracin zinc toxicity is strong, and not easy to be absorbed, it can not be used as a systemic infection treatment. | [Biological functions]
Bacitracin zinc is a medicine applied to cuts and other skin wounds to help prevent infection. bacitracin is a germ-killing medicine called an antibiotic. peptide antibiotics have a strong antibacterial effect on the gram positive bacteria, also has antibacterial effect to a small number of Gram-negative bacteria, and the spiral and actinomycetes and resistant to penicillin resistant Staphylococcus aureus.The antibacterial mechanism inhibits for the formation of damage and bacterial cell wall. The bacterial cytoplasmic membrane can promote beneficial intestinal microbial growth, increased intestinal permeability, promote the absorption of nutrients. Mainly used to promote the growth of livestock and poultry, livestock and poultry as well as prevention and treatment of bacterial diarrhea caused by Treponema pig dysentery. Oral administration of bacitracin zinc is almost no absorption, mostly in 2 days with the feces. So it is not easy to remain in the livestock and poultry products; bacteria to bacitracin produced very little resistance, and other antibiotics nor cross resistance and with penicillin, streptomycin, neomycin, streptomycin, mostly clay bacteria and have a synergistic effect. This product is toxic, not injection. The goods and olaquindox, guitar mold, mold of Virginia, Pinella mildew element existence is incompatibility. | [Uses]
1. Bacitracin zinc is used as feed additive for promoting the growth of livestock and poultry, prevention and treatment of livestock and poultry bacterial diarrhea and dense helicoid is caused by blood dysentery. Oral administration of zinc bacitracin is almost no absorption, mostly in 2 days with the feces. So it is not easy to remain in the livestock and poultry products; bacteria to bacitracin produced very little resistance, and other antibiotics nor cross resistance and with penicillin, streptomycin, neomycin, streptomycin, mostly clay bacteria and have a synergistic effect. This product is toxic, not injection. The goods and olaquindox, guitar mold, mold of Virginia, Pinella mildew element existence is incompatibility.
2. Bacitracin zinc is a polypeptide antibiotic, against gram positive bacteria with a bactericidal effect, its mechanism is mainly inhibiting the synthesis of bacterial cell wall of bacteria, can also with sensitive bacteria cell membrane combined injury of cell membrane integrity, resulting in cells of the important materials in the outflow. Effectively inhibit gram positive bacteria and some gram negative bacteria; bacteria on resistance of bacitracin zinc slower, and other antibiotics without cross resistance.
3. Peptide antibiotics, can inhibit the phosphorylation of pyrophosphate lipid, thereby inhibiting the synthesis of bacterial cell walls. |
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