| Identification | Back Directory | [Name]
COLISTIN | [CAS]
1066-17-7 | [Synonyms]
COLISTIN
kangdisu
totazina
colimycin
colomycin
coly-mycin
colymysins
kolimitsin
Aids033059
Aids-033059
colisticina
Polyoxin W.P.
1264-72-8 (Sulfate)
PolyMyxin E coMplex
Polymyxin E1 sulfate
Colistin, ColiMycin M, BelcoMycin, ColyMycin, Torazin
[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(1S,4S,7R,10S,13S,16S,19S)-4,13,16-tris(2-aminoethyl)-19-[(1R)-1-hydroxyethyl]-10-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-7-(phenylmethyl)-3,6 | [EINECS(EC#)]
213-907-3 | [Molecular Formula]
C52H98N16O13 | [MDL Number]
MFCD05662338 | [MOL File]
1066-17-7.mol | [Molecular Weight]
1155.43 |
| Chemical Properties | Back Directory | [Boiling point ]
807.67°C (rough estimate) | [density ]
1.1050 (rough estimate) | [refractive index ]
1.6700 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
PBS (pH 7.2): 10 mg/ml | [CAS DataBase Reference]
1066-17-7 |
| Hazard Information | Back Directory | [Uses]
Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect. | [Brand name]
Coly-Mycin (Monarch). | [storage]
Store at -20°C |
| Safety Data | Back Directory | [RIDADR ]
3249 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Hazardous Substances Data]
1066-17-7(Hazardous Substances Data) | [Toxicity]
cat,LDLo,subcutaneous,250mg/kg (250mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Antibiotiki. Vol. 5(4), Pg. 10, 1960. |
| Questions And Answer | Back Directory | [Neurotoxicity and Nephrotoxicity]
Colistin is an antibiotic which is being used more commonly now than when it was introduced because of its activity against multiresistant Gram-negative bacteria, especially Acinetobacter baumanii and Enterobacteriaceae producing extended spectrum β-lactamases. It had a bad reputation due to reports of neurotoxicity and nephrotoxicity. Recent studies have shown lower rates of nephrotoxicity than previously reported. However, in one of these reports, 7/42 patients with high serum creatinine values prior to colistin treatment developed renal failure.
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