| Identification | More | [Name]
4-Fluorobenzylamine | [CAS]
140-75-0 | [Synonyms]
4-FLUOROBENZYLAMINE
AKOS BBS-00003618
AURORA KA-7685
LABOTEST-BB LTBB000702
P-FLUOROBENZYLAMINE
RARECHEM AL BW 0026
(4-Fluorophenyl)methanamine
4-fluoro-benzenemethanamin
Benzylamine, p-fluoro-
4-fluoroBenzenemethanamine
4-FLUOROBENZYLAMINE, 97+%
Para Fluorobenzyamine
Benzenemethanamine, 4-fluoro-
4-Fluorobenzylamine 98%
4-FLUOROBENZYLAMINE 98+%
[(4-Fluorophenyl)methyl]amine
1-(4-Fluorophenyl)methanamine
NSC 158269
4-Fluorobenzylamine ,99% | [EINECS(EC#)]
205-430-4 | [Molecular Formula]
C7H8FN | [MDL Number]
MFCD00008120 | [Molecular Weight]
125.14 | [MOL File]
140-75-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Melting point ]
183 °C | [Boiling point ]
183 °C (lit.) | [density ]
1.095 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.512(lit.)
| [Fp ]
152 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Liquid | [pka]
9.01±0.10(Predicted) | [color ]
Clear colorless to light yellow | [Specific Gravity]
1.101.095 | [Water Solubility ]
Soluble in water. | [Sensitive ]
Air Sensitive | [Usage]
A benzylamine derivative as a potassium channel blocking agent. | [Detection Methods]
GC | [BRN ]
636501 | [InChIKey]
IIFVWLUQBAIPMJ-UHFFFAOYSA-N | [CAS DataBase Reference]
140-75-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenemethanamine, 4-fluoro-(140-75-0) | [EPA Substance Registry System]
Benzenemethanamine, 4-fluoro- (140-75-0) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/39:Wear suitable protective clothing and eye/face protection . | [RIDADR ]
UN 2735 8/PG 2
| [WGK Germany ]
3
| [F ]
10-34 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29214980 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
A benzylamine derivative as a potassium channel blocking agent. | [General Description]
[18F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate. It is an important building block for the synthesis of 18F-labeled compounds. | [Synthesis]
In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%. |
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