成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->1392275-56-7

1392275-56-7

1392275-56-7 Structure

1392275-56-7 Structure
IdentificationBack Directory
[Name]

Tenofovir Alafenamide Fumarate
[CAS]

1392275-56-7
[Synonyms]

Anti-HIV
API-Anti-HBV
Tenofovir Alafenamid
GS-7340 (hemifumarate)
Alafenamide hemifumarate
Tenofovir levamide amine fumarate
Tenofovir Alafenamide fumarate [USAN]
GS7340(Tenofovir Alafenamide Fumarate)
Tenofovir Alafenamide Hemifumarate(2:1)
Tenofovir Alafenamide Fumarate USP/EP/BP
(Tenofovir alafenamide : fumarate = 2:1)
Tenofovir Alafenamide Hemifumarate salt[USAN
TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE)
N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester
(R)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate
(S)-isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate hemifumarate
(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1)
N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1)
L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1)
[EINECS(EC#)]

805-448-8
[Molecular Formula]

2(C21H29N6O5P).C4H4O4
[MDL Number]

MFCD30534429
[MOL File]

1392275-56-7.mol
[Molecular Weight]

592.55
Chemical PropertiesBack Directory
[storage temp. ]

Keep in dark place,Sealed in dry,Room Temperature
[solubility ]

DMSO:75.0(Max Conc. mg/mL);70.16(Max Conc. mM)
[form ]

Solid
[color ]

White to off-white
[CAS DataBase Reference]

1392275-56-7
Hazard InformationBack Directory
[Description]

Tenofovir Alafenamide Fumarate is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of hepatitis B virus infection (HBV) in adults who meet certain requirements, as determined by a health care provider.
[Chemical Properties]

White to almost White crystal or crystalline powder.
[Originator]

Gilead Sciences
[Uses]

Tenofovir Alafenamide Fumarate is used to treat chronic hepatitis B virus (HBV) infection in adults with compensated liver disease.
[Definition]

ChEBI: A fumarate salt prepared from tenofovir alafenamide by reaction of one molecule of fumaric acid for every two molecules of tenofovir alafenamide. A prodrug for tenofovir, it is used in combination therapy for the treatment of HIV-1 infection.
[Clinical Use]

Tenofovir alafenamide hemifumarate is useful in the treatment and/or prophylaxis of one or more viral infections in man or animals, including infections caused by DNA viruses. RNA viruses, herpesviruses (e.g., CMV, HSV 1, HSV 2, VZV), retroviruses, hepadnaviruses (e.g., HBV), papillomavirus, hantavirus, adenoviruses and HIV. Like tenofovir disoproxil, tenofovir alafenamide is another prodrug form of tenofovir, and can be used in the treatment and/or prophylaxis of the same conditions.
[Side effects]

Check with your doctor immediately if any of the following side effects occur:
Abdominal or stomach discomfort,bloody urine,dark urine,decreased appetite,decreased frequency or amount of urine,troubled breathing,cough,headache,back pain.
[Synthesis]

Under a nitrogen atmosphere, 200 g of isopropanol, 9 g of fumaric acid, and 50 g of TAF-3 were sequentially added to a 2 L reaction flask. Turn on the stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, filter while hot, collect the mother liquor. Transfer the mother liquor to a 2L reaction bottle, start stirring, control the temperature at 40 ~ 50 °C, stir and dissolve, slowly reduce the temperature to 0 ~ 5 ° C, cooling time 2 ~ 3 hours, heat stirring for 10 hours. Filtration, drying at 60-65 ° C for 12 to 16 hours, to obtain 37.5 g of Tenofovir Alafenamide Fumarate finished product, white powder, yield 75.0%.
1392275-56-7.png
[Drug interactions]

Some products that may interact with this drug are: adefovir, orlistat, other drugs that may harm the kidneys (including aminoglycosides such as amikacin/gentamicin).
[storage]

Store at -20°C
[Advantages]

One major advantage of the hemifumarate form of tenofovir alafenamide over the monofumarate form is its exceptional capability to purge GS-7339 (i.e., 9-[(R)-2-[[(R)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine, which is the major diastereomeric impurity in the active pharmaceutical ingredient. Thus, the hemifumarate form of tenofovir alafenamide can be more readily and easily separated from impurities than the monofumarate form. Other major advantages of tenofovir alafenamide hemifumarate over the monofumarate form include improved thermodynamic and chemical stability (including long-term storage stability), superior process reproducibility, superior drug product content uniformity, and a higher melting point.
1392275-56-7 suppliers list
Company Name: Zison Pharmaceutical (Shandong) Co., Ltd.
Tel: +86-0086-531-88259693 +86-18660188356 , +86-18660188356
Website: https://www.zisonpharm.com/
Company Name: ENBRIDGE PHARMTECH CO., LTD.
Tel: +8613812269233 , +8613812269233
Website: http://m.is0513.com/manufacturer/enbridge-pharmtech-240/
Company Name: Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.
Tel: +8615065888978 , +8615065888978
Website: m.is0513.com/ShowSupplierProductsList1824669/0.htm
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Sinoway Industrial co., ltd.
Tel: 0592-5800732; +8613806035118 , +8613806035118
Website: https://www.china-sinoway.com/
Company Name: Hebei Yanxi Chemical Co., Ltd.
Tel: +8617531190177 , +8617531190177
Website: m.is0513.com/manufacturer/hebei-yanxi-chemical-283/
Company Name: Henan Bao Enluo International TradeCo.,LTD
Tel: +86-17331933971 +86-17331933971 , +86-17331933971
Website: baoenluo.guidechem.com/
Company Name: Shaanxi TNJONE Pharmaceutical Co., Ltd
Tel: +8618092446649 , +8618092446649
Website: tnjone.com
Company Name: BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Tel: +86-18600796368 +86-18600796368 , +86-18600796368
Website: http://www.sjar-tech.com/
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-(0)57185586718 +86-13336195806 , +86-13336195806
Website: www.capot.com
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Website: en.nanjing-pharmaceutical.com
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Website: http://www.cooperate-pharm.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714 , +8615858145714
Website: www.fandachem.com/
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: Lianyungang happen teng technology co., LTD
Tel: 15950718863
Website: m.is0513.com/ShowSupplierProductsList30820/0.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: TianYuan Pharmaceutical CO.,LTD
Tel: +86-755-23284190 13684996853
Website: www.tianpharm.com
Tags:1392275-56-7 Related Product Information
379270-37-8 147127-20-6 1446486-33-4 383365-04-6 2053424-88-5 342631-41-8 1246812-43-0 2053424-82-9 1422284-17-0 201341-05-1 160616-04-6 1093279-77-6 1255525-18-8 1234081-04-9 2055343-42-3 1883563-86-7 1948248-12-1 1607007-18-0