| Identification | More | [Name]
1-Acetylpiperazine | [CAS]
13889-98-0 | [Synonyms]
1-ACETYLPIPERAZINE
1-PIPERAZIN-1-YL-ETHANONE
AKOS BB-5737
N-ACETYLPIPERAZINE
acetylpiperazine
N-Acetylpiperazine97%
N-Acetylpiperazine,99%
n-acetyl ptperazine
N-aetylpiperazine
N-ACETY PIPERAZINE
1-Piperazinoethanone | [EINECS(EC#)]
237-659-0 | [Molecular Formula]
C6H12N2O | [MDL Number]
MFCD00058676 | [Molecular Weight]
128.17 | [MOL File]
13889-98-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear light yellow liquid after melting | [Melting point ]
31-34 °C (lit.) | [Boiling point ]
127 °C | [density ]
1.0754 (rough estimate) | [refractive index ]
1.4880 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
methanol: soluble1g/10 mL, clear, colorless to faintly greenish-yellow | [form ]
Liquid After Melting | [pka]
8.50±0.10(Predicted) | [color ]
Clear light yellow | [Water Solubility ]
Soluble in water 210 g/L (20°C). | [Sensitive ]
Hygroscopic | [Detection Methods]
GC | [BRN ]
112220 | [CAS DataBase Reference]
13889-98-0(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
3-10-34 | [Hazard Note ]
Irritant | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow liquid after melting | [Uses]
1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines. | [Definition]
ChEBI: 1-Acetylpiperazine is a member of phytanoyl-CoAs. | [General Description]
Infrared and Raman spectra of 1-acetylpiperazine have been recorded in the region of 4000-40cm-1. | [Purification Methods]
Purify 1-acetylpiperazine by recrystallisation from 40% aqueous EtOH or from EtOH/Et2O. It is an irritant, and is hygroscopic. The hydrochloride has m 191o (from EtOH), and the tosylate salt has m 148-149o (from EtOH/EtOAc, 1:16). The free base, however, cannot be isolated by basifying the tosylate salt and extraction with CH2Cl2. [Jacobi Chem Ber 66 113 1933, Mosher et al. J Am Chem Soc 75 4949 1953, Hall J Am Chem Soc 78 2570 1956, Beilstein 23 IV 1786.] |
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