| Identification | More | [Name]
Ramosetron hydrochloride | [CAS]
132907-72-3 | [Synonyms]
(1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride
RAMOSETRON HCL
RAMOSETRON HYDROCHLORIDE
(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon
(r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr
(r)-monohydrochlorid
ym060
RAMOSETRON HYDROCHLORIDE 98.5% MIN
(-)-5-(R)-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride
Ramosetron Hydrochlorid
Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-
Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-, monohydrochloride (9CI)
(R)-YM-060
Nasea OD | [Molecular Formula]
C17H18ClN3O | [MDL Number]
MFCD00894748 | [Molecular Weight]
315.8 | [MOL File]
132907-72-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
244-246°C | [alpha ]
D -42.9° (c 1.02 in methanol) | [storage temp. ]
-20°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
powder | [color ]
white to beige | [optical activity]
[α]/D -40 to -45°, c = 1 in methanol | [Stability:]
Hygroscopic | [InChIKey]
XIXYTCLDXQRHJO-RFVHGSKJSA-N | [CAS DataBase Reference]
132907-72-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [WGK Germany ]
3 | [Toxicity]
dog,LD,intravenous,> 30mg/kg (30mg/kg),SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE,Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994. |
| Hazard Information | Back Directory | [Description]
Nasea was launched in Japan for chemotherapy-induced emesis. Nasea
was prepared by a four step sequence via the Vilsmeier-type coupling of 1-
methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl -benzimidazole
hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor
antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times
more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and
was 8670 times more potent than netoclopramide. | [Chemical Properties]
White Solid | [Originator]
Yamanouchi (Japan) | [Uses]
Selective serotonin 5HT3, receptor antagonist; structurally different from Ondansetron (O655000), Granisetron (G780000). Antiemetic. | [Definition]
ChEBI: Ramosetron hydrochloride is a member of indoles. | [Brand name]
Nasea | [Biochem/physiol Actions]
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively. | [storage]
Store at -20°C |
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