| Identification | More | [Name]
Fmoc-N-trityl-L-asparagine | [CAS]
132388-59-1 | [Synonyms]
FMOC-ASN(TRT)
FMOC-ASN(TRT)-OH
FMOC-ASN(XAN)-OH
FMOC-ASPARAGINE(TRT)
FMOC-L-ASN(TRITYL)
FMOC-L-ASN(TRT)-OH
FMOC-L-ASPARAGINE(TRITYL)
FMOC-L-ASPARAGINE (TRT)
FMOC-L-ASPARGINE(TRITYL)
FMOC-N-BETA-TRITYL-L-ASPARAGINE
FMOC-N-GAMMA-TRITYL-L-ASPARAGINE
FMOC-N-GAMMA-XANTHYL-L-ASPARAGINE
FMOC-NG-TRITYL-L-ASPARAGINE
FMOC-N-TRITYL-L-ASPARAGINE
N-(9-FLUORENYL METHOXY CARBONYL)-N-TRITYL-L-ASPARAGINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-BETA-TRITYL-L-ASPARAGINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-BETA-XANTHYL-L-ASPARAGINE
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-TRITYL-L-ASPARAGINE
N-ALPHA-9-FLUORENYLMETHOXYCARBONYL-N-OMEGA-TRITYL-L-ASPARAGINE
NALPHA-(9-FLUORENYLMETHOXYCARBONYL)-NR-TRITYL-L-ASPARAGINE | [Molecular Formula]
C38H32N2O5 | [MDL Number]
MFCD00077049 | [Molecular Weight]
596.67 | [MOL File]
132388-59-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystal powde | [Melting point ]
201-204 °C(lit.)
| [alpha ]
-16 º (c=1, MeOH) | [Boiling point ]
858.1±65.0 °C(Predicted) | [density ]
1.271±0.06 g/cm3(Predicted) | [refractive index ]
-19 ° (C=1, DMF) | [storage temp. ]
2-8°C
| [solubility ]
<0.00005g/l | [form ]
powder to crystal | [pka]
3.79±0.10(Predicted) | [color ]
White to Almost white | [optical activity]
[α]20/D 15.0±1°, c = 1% in methanol | [Detection Methods]
T,NMR,Rotation | [BRN ]
4343823 | [InChIKey]
KJYAFJQCGPUXJY-UUWRZZSWSA-N | [SMILES]
C(O)(=O)[C@H](CC(N)=O)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 | [CAS DataBase Reference]
132388-59-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
53 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
2
| [F ]
3-10 | [HazardClass ]
IRRITANT | [HS Code ]
29242990 | [Toxicity]
LD50 orally in Rabbit: > 2000 mg/kg |
| Hazard Information | Back Directory | [Description]
Fmoc-Asn(Trt)-OH prevents the possibility of the amide side chain from undergoing dehydration side reactions during activation, especially with carbodiimide reagents. Fmoc-Asn(Trt)-OH dissolves readily in all standard peptide synthesis reagents, while Fmoc-Asn-OH is only somewhat soluble in NMP or DMF. The trityl group is removed with TFA. This reaction is usually complete within 1 hour at room temperature, but is slower when the Asn(Trt) residue in at the N-terminal of the peptide. In these cases, the deprotection reaction should be extended to 2 hours. | [Chemical Properties]
white crystal powde | [Uses]
Fmoc-Asn(Trt)-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry. | [Preparation]
Synthesis of Fmoc-Asn(Trt)-OH:
Step 1: Crystallization to form N'-Trityl-L-asparagine crystals.
Step 2: Centrifugation to extract N'-Trityl-L-asparagine crystals.
Step 3: Washing to remove residual starting materials in the synthesis.
Step 4: Extraction to obtain N-Acetyl-L-asparagine.
Step 5: Centrifugation to extract N'-Trityl-L-asparagine.
Step 6: Drying to obtain the final product.
This synthesis method effectively removes residual synthetic materials such as trifluoroacetic acid, maleic anhydride, and epichlorohydrin, which are similar in chemical properties to N-Acetyl-L-asparagine, from the product during the production process. The purification method is simple and the product obtained has high purity. |
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