| Identification | More | [Name]
Penicillin V potassium salt | [CAS]
132-98-9 | [Synonyms]
3,3-dimethyl-7-oxo-6-(2-phenoxy-acetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monopotassium salt
PENICILLINE V POTASSIUM SALT
PENICILLIN V
PENICILLIN VK
PENICILLIN V POTASSIUM
PENICILLIN V POTASSIUM SALT
PHENOXYMETHYLPENICILLINIC ACID POTASSIUM SALT
PHENOXYMETHYLPENICILLIN K+ SALT
PHENOXYMETHYLPENICILLIN POTASSIUM
PHENOXYMETHYL PENICILLIN POTASSIUM SALT
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-6-((ph
abicyclo[3.2.0]heptane-2-carboxylate
antibiocin
apsinvk
arcacil
arcasin
aspinvk
beromycin
beromycin(penicillin)
betapen-vk | [EINECS(EC#)]
205-086-5 | [Molecular Formula]
C16H17KN2O5S | [MDL Number]
MFCD00051771 | [Molecular Weight]
388.48 | [MOL File]
132-98-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
197-202°C | [alpha ]
D25 +223° (c = 0.2) | [density ]
1.40 | [storage temp. ]
2-8°C | [solubility ]
Freely soluble in water, practically insoluble in ethanol (96 per cent). | [form ]
neat | [color ]
Sol in water | [Water Solubility ]
Soluble in water, dimethyl sulfoxide, and methanol. | [BRN ]
3899451 | [BCS Class]
1 (CLogP), 3
(LogP) | [Stability:]
Hygroscopic | [InChIKey]
HCTVWSOKIJULET-LQDWTQKMSA-M | [CAS DataBase Reference]
132-98-9(CAS DataBase Reference) | [EPA Substance Registry System]
132-98-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [RTECS ]
XH9275000
| [TSCA ]
Yes | [HS Code ]
29411099 | [Hazardous Substances Data]
132-98-9(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: >1040 mg/kg (Goldenthal) |
| Hazard Information | Back Directory | [General Description]
Odorless white crystalline powder. Slightly bitter taste. pH (0.5% aqueous solution) 5 to 7.5. | [Reactivity Profile]
PENICILLIN VK+(132-98-9) is the potassium salt of penicillin v. This compound is incompatible with acids, oxidizing agents (especially in the presence of trace metals), heavy metal ions such as copper, lead, zinc and mercury; glycerol, sympathomimetic amines, thiomersal, wood alcohols, cetostearyl alcohol, hard paraffins, macrogols, cocoa butter and many ionic an nonionic surface-active agents. PENICILLIN VK+(132-98-9) is also incompatible with alkalis, compounds leached from vulcanized rubber, hydrochlorides of tetracyclines and organic peroxides. Other incompatibilities include reducing agents, alcohols, other hydroxy compounds, self-emulsifying stearyl alcohol, emulsifying wax, lanolin, crude cholinesterated bases, glycol, sugars, amines, aminacrine hydrochloride, ephedrine, procaine, rubber tubing, thiamine hydrochloride, zinc oxide, oxidized cellulose, iodine, iodides, thiols, chlorocresol and resorcinol. PENICILLIN VK+(132-98-9) may also be incompatible with naphthalene oils and vitamin B. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
Flash point data for this chemical are not available; however, PENICILLIN VK+ is probably combustible. | [Chemical Properties]
Crystalline Solid | [Originator]
Oracilline ,Theraplix ,France ,1954 | [Uses]
Penicillin antibacterial. | [Application]
Phenoxymethylpenicillin potassium was first obtained at Lilly Research Laboratories in 1948, following the addition of phenoxyacetic acid to a culture of Penicillium chrysogenum. Its industrial-scale production was established in 1953. Its usefulness as an orally active penicillin was suggested by Spitzy et al. in 1955. It is less hygroscopic and much more stable against gastric acid than benzylpenicillin, and it has been used orally for therapy of infections caused by Streptococcus, Staphylococcus, and other gram-positive bacteria as well as Neisseria and Leptospira. | [Definition]
ChEBI: Phenoxymethylpenicillin potassium is an organic potassium salt. It contains a phenoxymethylpenicillin(1-). | [Manufacturing Process]
The following description is taken from US Patent 2,941,995. A solution of phenoxyacetyl chloride (360 mg) in dry acetone (5 ml) was added dropwise during 10 minutes to a stirred solution of 6-aminopenicillanic acid (450 mg, approximately 75% pure) in 3% aqueous bicarbonate (18 ml), and acetone (12 ml). When addition was complete the mixture was stirred at room temperature for 30 minutes and then extracted with ether (30 ml in 3 portions), only the aqueous phase being retained. This aqueous solution was covered with butanol (5 ml) and adjusted to pH 2 by the addition of N hydrochloric acid. After separating the layers, the aqueous phase was extracted with two 2.5 ml portions of butanol, adjusting to pH 2 each time. The combined butanol solutions (which at this stage contained the free penicillanic acid) were washed with water (3 x 2 ml) and then shaken with water (10 ml) to which sufficient 3% sodium bicarbonate solution was added to bring the aqueous phase to pH 7. The butanol solution was further extracted with two 5 ml portions of water to each of which was added enough bicarbonate solution to produce an aqueous phase of pH 7. The combined aqueous solutions were washed with ether (20 ml) and then evaporated at low temperature and pressure to leave the crude sodium salt of phenoxymethyl penicillin which, after drying in a vacuum desiccator, was obtained as a slightly hygroscopic powder (591 mg). | [Brand name]
V-Cillin(Lilly). | [Therapeutic Function]
Antibacterial | [Safety Profile]
Moderately toxic by ingestion, intramuscular, intraperitoneal, and intravenous routes. Human mutation data reported. Questionable carcinogen with no experimental evidence. When heated to decomposition it emits very toxic fumes of NOx, K2O, and SOx. Used | [storage]
Store at 2-8°C |
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