| Identification | More | [Name]
2,4,7-TRINITRO-9-FLUORENONE | [CAS]
129-79-3 | [Synonyms]
2,4,7-TRINITRO-9-FLUORENONE
2，4，7-Trinitrofluoren-9-one
2,4,7-TRINITROFLUORENONE
LABOTEST-BB LT00645370
2,4,7-trinitro-9h-fluoren-9-on
2,4,7-Trinitro-9H-fluoren-9-one
2,4,7-trinitro-fluoren-9-on
2,4,7-trinitrofluorone
9-fluorenone,2,4,7-trinitro-
9H-Fluoren-9-one, 2,4,7-trinitro-
Fluoren-9-one, 2,4,7-trinitro-
TNF
tnf(ketone)
2,4,7-Trinitro-9-fluorenone (wetted with ca. 20% Water, containing 5g
2,4,7-Trinirofluorenone
2,4,7-TRINITRO-9-FLUORENONE(WETTEDWITHCA.20%WATER,CONTAINING5GONADRYWEIGHTBASIS)
TRINITROFLUORENONE
2,4,-TRINITRO-9-FLUORENONE (100UG/ML IN TOLUENE) | [EINECS(EC#)]
204-965-0 | [Molecular Formula]
C13H5N3O7 | [MDL Number]
MFCD00001142 | [Molecular Weight]
315.19 | [MOL File]
129-79-3.mol |
| Safety Data | Back Directory | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects. | [Safety Statements ]
S9:Keep container in a well-ventilated place .
S16:Keep away from sources of ignition-No smoking .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
387 | [WGK Germany ]
3 | [HazardClass ]
1.1D | [PackingGroup ]
II | [Safety Profile]
Suspected carcinogen
with experimental tumorigenic data. Mildly
toxic by ingestion. Human mutation data
reported. A skin and eye irritant. When
heated to decomposition it emits hghly
toxic fumes of NOx. See also NITRO
COMPOUNDS of AROMATIC
HYDROCARBONS and KETONES. | [Hazardous Substances Data]
129-79-3(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 9910mg/kg |
| Hazard Information | Back Directory | [General Description]
Pale yellow needles (from acetic acid or benzene) or yellow powder. | [Reactivity Profile]
Literature sources indicate that this compound is flammable. . Aromatic nitrates range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Literature sources indicate that this compound is flammable. | [Uses]
TNF-α influences the growth and function of both normal and neoplastic cells. TNF-α causes cytolysis or cytostasis of certain transformed cells being synergistic with γ-interferon in its cytotoxicity. | [Uses]
Tumor Necrosis Factor-α from mouse, a potent proinflammatory cytokine has been used:
- to activate MS1 endothelium cells
- to induce lipolysis in adipocytes
- to study its effect on liganded and unliganded glucocorticoid receptor (GR) in interleukin (IL)-6 and IL-8 gene regulation
| [Hazard]
Suspected carcinogen. Mildly toxic by
ingestion. A skin and eye irritant. | [Biochem/physiol Actions]
The TNFA (tumor necrosis factor α) gene is significantly associated with the regulation of innate and adaptive immune responses. Polymorphism of TNFA gene is known to cause acute motor axonal neuropathy. The cytokine release and gene action is associated with epithelial cells, myeloid cells, endothelial, as well as tumor cells. Tumor cells are known to release TNFA, specifically in response to chemotherapy | [Purification Methods]
Crystallise it from nitric acid/water (3:1), wash it with water and dry it under vacuum over P2O5, or recrystallise it from dry *benzene. [Beilstein 7 II 410, 7 III 2348, 7 IV 1638.] |
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