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ChemicalBook--->CAS DataBase List--->1224713-90-9

1224713-90-9

1224713-90-9 Structure

1224713-90-9 Structure
IdentificationBack Directory
[Name]

3,5-DIHYDROXY-4'-BROMOSTILBENE
[CAS]

1224713-90-9
[Synonyms]

4-Bromo-Resveratrol
Resveratrol 4-Bromo Impurity
3,5-DIHYDROXY-4'-BROMOSTILBENE
4-Bromo-Resveratrol >=98% (HPLC)
(E)-5-(4-Bromostyryl)benzene-1,3-diol
5-[(E)-2-(4-bromophenyl)vinyl]resorcinol
Resveratrol Impurity 22 (4'-Bromo-resveratrol)
5-[(E)-2-(4-Bromophenyl)vinyl]benzene-1,3-diol
5-[(E)-2-(4-bromophenyl)ethenyl]benzene-1,3-diol
5-[(1E)-2-(4-Bromophenyl)ethenyl]-1,3-benzenediol
1,3-Benzenediol, 5-[(1E)-2-(4-bromophenyl)ethenyl]-
[EINECS(EC#)]

808-419-8
[Molecular Formula]

C14H11BrO2
[MDL Number]

MFCD00238583
[MOL File]

1224713-90-9.mol
[Molecular Weight]

291.14
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

powder
[color ]

white to yellow to brown
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26
[WGK Germany ]

3
[HazardClass ]

IRRITANT
Hazard InformationBack Directory
[Biological Activity]

4'-bromo-resveratrol is a sirt1 and sirt3 inhibitor.sirtuins are protein deacetylases regulating aging processes and many physiological functions. resveratrol activates human sirt1 and inhibits sirt3, and can mimic calorie restriction effects including lifespan extension in lower organisms.
[in vitro]

sirtuin modulation was studied by using 4’-bromo-resveratrol in a previous study. 4’-bromo-resveratrol inhibited sirt3 with much higher potency than resveratrol, and it also inhibited rather than activated sirt1. crystal structures of human sirt3/peptide complexes of 4’ -bromo-resveratrol identified two binding sites. an internal site caused the potent inhibitory effect. 4’-bromo-resveratrol interfered with nad+ and substrate peptide binding, and it extended its bromo-phenyl group in a unrecognized site pocket. the second binding site for 4’-bromo-resveratrol was found to be located on the surface of sirt3 and connected via two helices to peptide-binding active site loops. in sirt1, this site appeared to comprise a residue that was essential for its activation by small molecules and 4’-bromo-resveratrol therefore constituted a candidate for the long-sought allosteric sirt1 activator binding site [1].
[References]

[1] nguyen gt, gertz m, steegborn c. crystal structures of sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism. chem biol. 2013 nov 21;20(11):1375-85.
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