| Identification | Back Directory | [Name]
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID | [CAS]
121083-05-4 | [Synonyms]
L-670,596
2-(6,8-Difluoro-9-(4-(methylsulfonyl)benzyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID | [Molecular Formula]
C22H21F2NO4S | [MDL Number]
MFCD00880316 | [MOL File]
121083-05-4.mol | [Molecular Weight]
433.47 |
| Chemical Properties | Back Directory | [Boiling point ]
693.4±55.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in 1.1eq. NaOH | [form ]
Powder | [pka]
4.56±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
L-670,596 is a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. | [Definition]
ChEBI: 2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid is a member of carbazoles. | [Biological Activity]
Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo . | [in vivo]
L-670596 (0.03mg/kg ; i.v.; single) inhibits arachidonic acid and U-44069 induced bronchoconstriction in the guinea pig[1].
L-670596 (2 mg/kg; i.v.; single) inhibits platelet aggregation to collagen in pigs[2]. | Animal Model: | Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1]. | | Dosage: | 0.03mg/kg | | Administration: | Intravenous injection; single. | | Result: | Inhibited arachidonic acid and U-44069 induced bronchoconstriction. |
| [storage]
Store at RT |
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