| Identification | More | [Name]
Sulfanilic acid | [CAS]
121-57-3 | [Synonyms]
4-AMINOBENZENESULFONIC ACID
4-AMINOBENZENESULPHONIC ACID
4-AMINOBENZOIC ACID
4-ANILINESULFONIC ACID
4-SULFOANILINE
ANILINE-4-SULFONIC ACID
ANILINE P-SULFONIC ACID
NITRATE REAGENT B
P-AMINOBENZENESULFONIC ACID
P-ANILINESULFONIC ACID
P-SULFANILIC ACID
SUFANILIC ACID
SULFANILIC ACID
SULFANILIC ACID TS
SULFANILLIC ACID
SULPHANILIC ACID
4-amino-benzenesulfonicaci
Aniline-p-sulphonic acid
aniline-p-sulphonicacid
Kyselina sulfanilova | [EINECS(EC#)]
204-482-5 | [Molecular Formula]
C6H7NO3S | [MDL Number]
MFCD00007886 | [Molecular Weight]
173.19 | [MOL File]
121-57-3.mol |
| Chemical Properties | Back Directory | [Appearance]
greyish-white crystals or powder | [Melting point ]
>300 °C(lit.)
| [Boiling point ]
288 ℃ | [density ]
1.485 | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Store in dark! | [solubility ]
10g/l | [form ]
solid | [pka]
3.24(at 25℃) | [color ]
White to Off-White | [PH]
2.5 (10g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
0.1 g/100 mL (20 ºC) | [Merck ]
14,8926 | [BRN ]
908765 | [InChIKey]
HVBSAKJJOYLTQU-UHFFFAOYSA-N | [LogP]
-2.3 at 25℃ | [CAS DataBase Reference]
121-57-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenesulfonic acid, 4-amino-(121-57-3) | [EPA Substance Registry System]
121-57-3(EPA Substance) |
| Questions And Answer | Back Directory | [Synthesize]
Sulfanilic acid can be used for the determination of nitrite.
Biochemical Research. Organic Synthesis. Sulfanilic acid is an important
intermediate of sulfonamide drugs. This product has strong
antibacterial effect on hemolytic streptococcus, meningitis and coccus,
but due to poor efficacy and high toxicity, it is rarely used for oral
administration. It is also rarely used. It is used as an intermediate
for the synthesis of other sulfonamides, and is also used as a raw
material for the synthesis of agricultural "Huangcaoling" abroad.
Sulfanilic acid can also be used as an analytical reagent, such as a
reagent for the photometric determination of nitrite and sodium
nitroferricyanide. For biochemical research, organic synthesis and
pharmaceutical industry. Sulfanilic acid is the main raw material for
synthesizing sulfonamides. In addition to preparing crystalline
sulfonamides for external anti-inflammatory, it can also synthesize
other sulfonamides such as sulfamidine, sulfamethoxazine, and
sulfamethazine. |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin .
R43:May cause sensitization by skin contact.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37:Wear suitable gloves .
S24:Avoid contact with skin . | [RIDADR ]
UN 2790 8/PG 3
| [WGK Germany ]
1
| [RTECS ]
WP3895500
| [Autoignition Temperature]
>400 °C | [TSCA ]
Yes | [HS Code ]
29214210 | [Hazardous Substances Data]
121-57-3(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 12300 mg/kg |
| Hazard Information | Back Directory | [General Description]
White powder with faint purple tinge. Grayish-white flat crystals. Becomes anhydrous at around 212°F. Low toxicity (used medicinally). | [Reactivity Profile]
4-AMINOBENZENE SULFONIC ACID(121-57-3) is an amino acid. Reacts weakly with both acids and bases. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available, however 4-AMINOBENZENE SULFONIC ACID is probably combustible. | [Description]
Sulfanilic acid (4-amino benzene sulfonic acid ) is an off-white crystalline solid which finds application in quantitative analysis of nitrate and nitrite ions. The solid acid exists as a zwitterion, and has an unusually high melting point. | [Chemical Properties]
greyish-white crystals or powder | [Uses]
A toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial. | [Application]
As the compound readily form diazo compounds, it is used to make dyes and sulpha drugs . This property is also used for the quantitative analysis of nitrate and nitrite ions by diazonium coupling reaction with N-(1-Naphthyl) ethylene diamine , resulting in an azo dye, and the concentration of nitrate or nitrite ions were deduced from the color intensity of the resulting red solution by colorimetry.
It is also used as a standard in combustion analysis. | [Definition]
ChEBI: An aminobenzenesulfonic acid that is aniline sulfonated at the para-position. | [Synthesis]
Sulfanilic acid can be produced by sulfonation of aniline. | [Purification Methods]
Crystallise the acid (as dihydrate) from boiling water. Dry it at 105o for 2-3hours, then over 90% H2SO4 in a vacuum desiccator. The S-benzylisothiuronium salt has m 187o (from aqueous EtOH). [Beilstein 14 IV 2655.] |
|
|