| Identification | More | [Name]
(R)-(+)-1,2-Dithiolane-3-pentanoic acid | [CAS]
1200-22-2 | [Synonyms]
(R)-(+)-1,2-DITHIOLANE-3-PENTANOIC ACID
R-(+)-ALPHA-LIPOIC ACID
R-ALPHA-LIPOIC ACID
(R)-LIPOIC ACID
(R)-(+)-Thioctic Acid
R-(+)-Alpha-Lipoic Acid 1200-22-2
(3R)-1,2-Dithiolane-3-pentanoic Acid
(R)-(+)-a-Lipoic Acid
Byodinoral 300
Lipoec
Thiogamma
Tiobe
1,2-Dithiolane-3-pentanoic acid, (3R)-
LIPOIC ACID (D-LIPOIC ACID)
R-A-LIPOIC ACID (D-LIPOIC ACID)
1,2-Dithiolane-3-pentanoic acid, (3R)-(9CI)
1,2-Dithiolane-3-pentanoic acid, (R)-
Tiobec
R (+) Alpha lipoic Acid ( D-Form)
(R)-1,2-Dithiolane-3-valeric Acid | [EINECS(EC#)]
638-752-2 | [Molecular Formula]
C8H14O2S2 | [MDL Number]
MFCD01631142 | [Molecular Weight]
206.33 | [MOL File]
1200-22-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
48-52 °C(lit.)
| [alpha ]
D23 +104° (c = 0.88 in benzene) | [Boiling point ]
185-195 °C(Press: 0.5 Torr) | [density ]
1.218±0.06 g/cm3(Predicted) | [refractive index ]
114 ° (C=1, EtOH) | [Fp ]
>230 °F
| [storage temp. ]
-20°C | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly), DMSO | [form ]
Solid | [pka]
5.4(at 25℃) | [color ]
Light Yellow to Yellow | [optical activity]
[α]20/D +104°, c = 1 in chloroform | [Usage]
A fat-metabolism stimulator | [Merck ]
9326 | [LogP]
2.160 (est) | [CAS DataBase Reference]
1200-22-2(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Solid | [Uses]
A fat-metabolism stimulator | [Definition]
ChEBI: (R)-lipoic acid is the (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties. It has a role as a prosthetic group, a nutraceutical and a cofactor. It is a lipoic acid, a member of dithiolanes, a heterocyclic fatty acid and a thia fatty acid. It is functionally related to an octanoic acid. It is a conjugate acid of a (R)-lipoate. It is an enantiomer of a (S)-lipoic acid. | [General Description]
α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms. | [Biochem/physiol Actions]
(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease. |
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