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ChemicalBook--->CAS DataBase List--->119615-63-3

119615-63-3

119615-63-3 Structure

119615-63-3 Structure
IdentificationBack Directory
[Name]

OLPRINONE HYDROCHLORIDE
[CAS]

119615-63-3
[Synonyms]

e1020
Coretec
OLPRINONE HCL
xo-,monohydrochloride,monohydrate
3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o
1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride
3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride
[Molecular Formula]

C14H10N4O.ClH.H2O
[MDL Number]

MFCD01749474
[MOL File]

119615-63-3.mol
[Molecular Weight]

304.736
Chemical PropertiesBack Directory
[Appearance]

Off-White Crystalline Powder
[Melting point ]

>3000C
[storage temp. ]

2-8°C
[solubility ]

DMSO: ≤4 mg/mL
[form ]

solid
[color ]

beige
Hazard InformationBack Directory
[Chemical Properties]

Off-White Crystalline Powder
[Uses]

Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic
[Description]

Coatec was launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. There are three related synthetic routes, 5-6 steps each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused increased levels of CAMP which leads to the positive inotropic effect that was not altered by β or H2-preceptor antagonists. It was 100 times less potent at PDE I and PDE Ⅱ with no Na-K-ATPase activity. Improved hemodynamic parameters with slight changes in heart rate and blood pressure were seen in vivo. It is not mutagenic and its primary metabolite was less active.
[Originator]

Eisai (Japan)
[Definition]

ChEBI: Olprinone hydrochloride is an organic molecular entity.
[Brand name]

Coatec
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

2
[RTECS ]

US4201450
Spectrum DetailBack Directory
[Spectrum Detail]

OLPRINONE HYDROCHLORIDE(119615-63-3)1HNMR
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