| Identification | More | [Name]
1(2H)-Phthalazinone | [CAS]
119-39-1 | [Synonyms]
1,2-DIHYDROPHTHALAZIN-1-ONE
1(2H)-PHTHALAZINONE
1,2H-PHTHALAZONE
1,3-DIHYDRO-4-KETO-2 3-BENZODIAZINE
BENZO[D]PYRIDAZIN-1(2H)ONE
DIHYDROOXOPHTHALAZINE
PHTHALAZONE
PTLZ
1-phthalazinol
phthalazin-1-one
phthalazinone
Phthalazin-1(2H)-one
2,3-Phthalazinone
2H-Phthalazin-1-one
1(2H)-Phthalazinone, 98+%
1,2-Dihydrophthalazine-1-one
Pthalazone | [EINECS(EC#)]
204-319-8 | [Molecular Formula]
C8H6N2O | [MDL Number]
MFCD00006892 | [Molecular Weight]
146.15 | [MOL File]
119-39-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-white to pale yellow crystalline powder | [Melting point ]
183-185 °C(lit.)
| [Boiling point ]
337°C(lit.) | [density ]
1.2312 (rough estimate) | [refractive index ]
1.4900 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
12.29±0.20(Predicted) | [color ]
Off-white to pale yellow | [BRN ]
3654 | [InChIKey]
IJAPPYDYQCXOEF-UHFFFAOYSA-N | [CAS DataBase Reference]
119-39-1(CAS DataBase Reference) | [EPA Substance Registry System]
119-39-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R68:Possible risk of irreversible effects.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
TH9185000
| [HazardClass ]
IRRITANT | [HS Code ]
29339990 | [Hazardous Substances Data]
119-39-1(Hazardous Substances Data) | [Toxicity]
mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00139, |
| Hazard Information | Back Directory | [General Description]
Pale yellow crystals. Insoluble in water. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available. 1-(2H)-PHTHALAZINONE is probably combustible. | [Chemical Properties]
Off-white to pale yellow crystalline powder | [Uses]
Phthalazone is a remarkable scaffold in drug discovery. Also, functions as an oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase. | [Definition]
ChEBI: Phthalazin-1(2H)-one is a member of phthalazines. | [Purification Methods]
Phthalazone crystallises from H2O or EtOH and sublimes in vacuo. [Beilstein 24 H 142, 24 24 III/IV 400.] |
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