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ChemicalBook--->CAS DataBase List--->117830-79-2

117830-79-2

117830-79-2 Structure

117830-79-2 Structure
IdentificationBack Directory
[Name]

ENTEROSTATIN, HUMAN
[CAS]

117830-79-2
[Synonyms]

APGPR Enterostatin
ALA-PRO-ASP-PRO-ARG
ALA-PRO-GLY-PRO-ARG
ENTEROSTATIN, HUMAN
H-ALA-PRO-GLY-PRO-ARG-OH
Enterostatin , mouse, rat)
L-ALA-PRO-GLY-PRO-ARG SALT
H-ALA-PRO-GLY-PRO-ARG-OH ACOH
procolipase activation peptide
ENTEROSTATIN (HUMAN) ACETATE SALT
HUMAN PROCOLIPASE ACTIVATION PEPTIDE
H-ALA-PRO-GLY-PRO-ARG-OH ACETATE SALT
L-Arginine, L-alanyl-L-prolylglycyl-L-prolyl-
[Molecular Formula]

C21H36N8O6
[MDL Number]

MFCD00133052
[MOL File]

117830-79-2.mol
[Molecular Weight]

496.56
Chemical PropertiesBack Directory
[density ]

1.54±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

Soluble to 0.70 mg/ml in sterile water
[form ]

Lyophilized solid.
[pka]

3.60±0.21(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Definition]

ChEBI: APGPR Enterostatin is a peptide.
[Biological Activity]

Enterostatin are pentapeptides that reduce fat intake.
[in vitro]

In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%).

[in vivo]

Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake.

[target]

Human Endogenous Metabolite

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Spectrum DetailBack Directory
[Spectrum Detail]

ENTEROSTATIN, HUMAN(117830-79-2)MS
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