| Identification | More | [Name]
H-8 DIHYDROCHLORIDE | [CAS]
113276-94-1 | [Synonyms]
H-8
H-8 HYDROCHLORIDE
H-8 DIHYDROCHLORIDE
H-8 dihydrochloride,98%
H8, dihydrochloride salt
H-8 dihydrochloride >98% (HPLC)
H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C
N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide
2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT
N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-5-SULFONAMIDE DIHYDROCHLORIDE
N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE
5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2) | [Molecular Formula]
C12H17Cl2N3O2S | [MDL Number]
MFCD00036962 | [Molecular Weight]
338.25 | [MOL File]
113276-94-1.mol |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29334990 |
| Hazard Information | Back Directory | [Description]
The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with Ki values of 1.2, 0.48, 15, and 68 μM, respectively.1,2,3 H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC50 values of 47 and 6.2 μM, respectively.4 | [Chemical Properties]
white to off-white crystalline solid | [Uses]
Active inhibitor of cyclic-nucleotide-dependent protein kinases. | [Biochem/physiol Actions]
cAMP and cGMP-dependent protein kinase inhibitor. | [storage]
Store at -20°C |
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