| Identification | Back Directory | [Name]
IM-12 | [CAS]
1129669-05-1 | [Synonyms]
IM-12
CS-1819
CS-2144
IM-12 USP/EP/BP
The GSK3β Inhibitor XIX
THE GSK3Β INHIBITOR XIX; IM 12; IM-12;IM12
3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione IM-12 | [Molecular Formula]
C22H20FN3O2 | [MDL Number]
MFCD20527313 | [MOL File]
1129669-05-1.mol | [Molecular Weight]
377.412 |
| Chemical Properties | Back Directory | [Melting point ]
187 °C | [Boiling point ]
600.2±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ≥9mg/mL | [form ]
powder | [pka]
16.77±0.30(Predicted) | [color ]
yellow-orange |
| Hazard Information | Back Directory | [Description]
Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM).1,2 It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain.2 IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.3 | [Uses]
GSK-3β inhibitor (IC50=53nM (enzymatic), 3.8μM (cellular)). The compound significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling. | [Definition]
ChEBI: 3-[2-(4-fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione is an organonitrogen compound, an organooxygen compound and a member of maleimides. It is functionally related to an alpha-amino acid. | [storage]
Store at -20°C | [References]
[1]. schm?le ac, brennführer a, karapetyan g, et al. novel indolylmaleimide acts as gsk-3beta inhibitor in human neural progenitor cells. bioorg med chem, 2010, 18(18): 6785-6795. |
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