| Identification | Back Directory | [Name]
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one | [CAS]
1124329-14-1 | [Synonyms]
CS-511
AZ 3146
1124329-14-1
AZ 3146; AZ-3146
AZ3146 >=98% (HPLC)
AZ3146; AZ 3146; AZ-3146
AZ3146 Mps1 Inhibitor III AZ-3146
9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one
9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9
9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one
9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
8H-Purin-8-one, 9-cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one USP/EP/BP
9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146 | [Molecular Formula]
C24H32N6O3 | [MDL Number]
MFCD18384959 | [MOL File]
1124329-14-1.mol | [Molecular Weight]
453 |
| Chemical Properties | Back Directory | [Boiling point ]
621.0±65.0 °C(Predicted) | [density ]
1.279 | [storage temp. ]
Store at +4°C | [solubility ]
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml) | [form ]
solid | [pka]
8.29±0.10(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2 | [Uses]
AZ 3146 is a protein kinase Mps1 inhibitor. | [Enzyme inhibitor]
This selective inhibitor (FW = 452.55 g/mL; CAS 1124329-14-1;
Solubility: 28 mg/mL DMSO; <1 mg/mL Water), also known as 9-
cyclopentyl-2- (2-methoxy-4- (1-methylpiperidin-4-yloxy) phenylamino) -7-
methyl-7H-purin-8 (9H) -one, inhibits MPS1 protein kinases (IC50 = 35 nM),
which are found widely, but not ubiquitously, in eukaryotes and regulate
kinetochore in both the chromosome attachment and the spindle
checkpoints. MPS1 kinases also regulate centrosome function. | [storage]
Store at +4°C | [References]
1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25
2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309 |
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