| Identification | More | [Name]
CALPAIN INHIBITOR II | [CAS]
110115-07-6 | [Synonyms]
ALLM
Calp II
SUAM 312
AC-LLM-CHO
Ac-Leu-Leu-Met-al
AC-LEU-LEU-MET-CHO
CALPAIN INHIBITOR II
AC-LEU-LEU-METHIONINAL
AC-LEU-LEU-MET-ALDEHYDE
AC-LEU-LEU-L-METHIONINAL
N-AC-LEU-LEU-METHIONINAL
N-ACETYL-LEU-LEU-MET-CHO
Calpain Inhibitor II,96%
AC-LEU-LEU-MET-H (ALDEHYDE)
N-ACETYL-LEU-LEU-METHIONINAL
N-Acetyl-L-Leu-L-Leu-L-Met-OH
n-acetylleucyl-leucyl-methioninal
N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONAL
ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL
CALPAIN INHIBITOR II ;AC-LEU-LEU-MET-CHO
N-ACETYL-L-LEUCYL-L-LEUCYL-L-METHIONINAL
L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formyl-3-(methylthio)propyl]- | [Molecular Formula]
C19H35N3O4S | [MDL Number]
MFCD00065506 | [Molecular Weight]
401.56 | [MOL File]
110115-07-6.mol |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white powder | [Uses]
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons. | [Definition]
ChEBI: N-Acetylleucyl-leucyl-methioninal is a peptide. | [General Description]
A cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. | [Biochem/physiol Actions]
Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation. |
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