| Identification | More | [Name]
Dihydropyran | [CAS]
110-87-2 | [Synonyms]
2,3-DIHYDRO-4H-PYRAN
3,4-DIHYDRO-2ETA-PYRAN
3,4-DIHYDRO-2H-PYRAN
3,4-DIHYDROPYRAN
5,6-DIHYDRO-4H-PYRAN
DHP
DIHYDROPYRAN
2H-3,4-Dihydropyran
2H-Pyran,3,4-dihydro-
3,4-Dihdro-2H-pyrane
3,4-dihydro-2h-pyra
3,4-Dihydro-2-pyran
delta(Sup2)-Dihydropyran
delta2-Dihydropyran
Pyran, dihydro-
pyran,dihydro-
δ2-dihydropyran
DIHYDROPYRANE
dihydro-2H-pyran
3,4-Dihydro-2H-pyrane | [EINECS(EC#)]
203-810-4 | [Molecular Formula]
C5H8O | [MDL Number]
MFCD00006558 | [Molecular Weight]
84.12 | [MOL File]
110-87-2.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to light yellow liqui | [Melting point ]
-70 °C (lit.) | [Boiling point ]
86 °C (lit.) | [density ]
0.922 g/mL at 25 °C(lit.)
| [vapor density ]
2.9 (vs air)
| [vapor pressure ]
77.8 hPa (20 °C) | [refractive index ]
n20/D 1.440(lit.)
| [Fp ]
4 °F
| [storage temp. ]
Flammables area | [solubility ]
7.7g/l | [form ]
Liquid | [color ]
Clear colorless to yellow | [PH]
7 (5g/l, H2O, 20℃) | [explosive limit]
1.1-13.8%(V) | [Water Solubility ]
20 g/L (20 ºC) | [BRN ]
103493 | [Stability:]
Volatile | [InChIKey]
BUDQDWGNQVEFAC-UHFFFAOYSA-N | [LogP]
0.690 | [CAS DataBase Reference]
110-87-2(CAS DataBase Reference) | [NIST Chemistry Reference]
2H-Pyran, 3,4-dihydro-(110-87-2) | [Storage Precautions]
Store under nitrogen | [EPA Substance Registry System]
110-87-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xi | [Risk Statements ]
R11:Highly Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/38:Irritating to eyes and skin .
R19:May form explosive peroxides. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
S33:Take precautionary measures against static discharges .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 2376 3/PG 2
| [WGK Germany ]
3
| [RTECS ]
UP7700000 | [Autoignition Temperature]
240 °C | [Hazard Note ]
Highly Flammable/Irritant | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29329995 | [Safety Profile]
A flammable and very
dangerous fire hazard when exposed to heat
or flame; can react vigorously with oxidzing
materials. Keep away from heat and open
flame. To fight fire, use alcohol foam, CO2,
or dry chemical. When heated to
decomposition it emits acrid smoke and
irritating | [Toxicity]
LD50 orally in Rabbit: > 4000 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Tetrahydrofurfuryl alcohol | [Preparation Products]
4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE-->Glutaraldehyde-->2-ethoxyoxane-->Pyrazole-3-boronic acid-->1-{2-[(Tetrahydro-2H-pyran-2-yl)oxy]ethyl}-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-->2-[(5-NITRO-2-FURYL)METHOXY]TETRAHYDRO-2H-PYRAN-->O-(Tetrahydro-2H-pyran-2-yl)hydroxylamine-->Tetrahydropyran-->3,4-DIHYDRO-2H-PYRAN-5-CARBALDEHYDE-->(S)-TETRAHYDRO-2H-PYRAN-3-OL-->2,5-DICHLOROHYDROQUINONE-->2-(3,4-Dihydro-2H-pyran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane-->2-METHOXYTETRAHYDROPYRAN-->N-Benzyl-9-(tetrahydro-2H-pyran-2-yl)adenine |
| Hazard Information | Back Directory | [Chemical Properties]
colorless to light yellow liqui | [Uses]
Widely used hydroxyl-protecting reagent3,4-Dihydro-2H-pyran is used as a hydroxyl-protecting reagent in organic synthesis. It acts as an intermediate in synthetic chemistry. It is used to protect various reactive functional groups. It is involved in the polymerization reaction either alone or with unsaturated compound and finds application in polymer industries. Further, it is employed in the preparation of bicyclic compounds of epoxide-fused, halo compounds and allenic alcohols. | [Flammability and Explosibility]
Flammable | [Purification Methods]
Partially dry dihydropyran with Na2CO3, then fractionally distil it. The fraction b 84-85o is refluxed with Na until hydrogen no longer evolves when fresh Na is added. It is then dried, and distilled again through a 60 x 1.2cm column packed with glass rings [Brandon et al. J Am Chem Soc 72 2120 1950, UV: Elington et al. J Chem Soc 2873 1952, NMR: Bushweller & O'Neil Tetrahedron Lett 4713 1969]. It has been characterised as the 3,5-dinitrobenzoyloxy-tetrahydrofuran derivative, m 103o which forms pale yellow crystals from dihydropyran/Et2O [Woods & Kramer J Am Chem Soc 69 2246 1947]. [Beilstein 17/1 V 181.] |
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