| Identification | Back Directory | [Name]
LY-2584702 (tosylate salt) | [CAS]
1082949-68-5 | [Synonyms]
LYS6K2
CS-2145
LY2584702 Tosylate
LY-2584702 (tosylate salt)
LY-2584702;LY 2584702;LYS6K2
LY2584702 Tosylate (LYS-6K2)
LYS6K2(LY2584702) tosylate salt
LY-2584702 (tosylate salt) USP/EP/BP
4-{4-[4-(4-fluoro-3-trifluoromethyl-phenyl)-1-methyl-1H-imidazol-2-yl]-piperidin-1-yl}-1H-pyrazolo[3,4-d]pyrimidine p-toluenesulfonate
4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate (1:1)
1H-Pyrazolo[3,4-d]pyrimidine,4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-,4-methylbenzenesulfonate (1:1) | [Molecular Formula]
C28H27F4N7O3S | [MDL Number]
MFCD29054739 | [MOL File]
1082949-68-5.mol | [Molecular Weight]
617.618 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:12.55(Max Conc. mg/mL);20.31(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
LY-2584702 is a p70 S6 kinase inhibitor with anti-tumor activity. | [Biological Activity]
LY2584702 is an orally activeATP-competitivepotent and selective ribosomal protein S6 kinase (p70 S6 kinasep70S6KS6K1) inhibitor (IC50 = 4 nM; selective over 83 other kinases and 45 cell surface markers). LY2584702 inhibits HCT116 cellular S6 phosphorylation (IC50 0.1-0.24 μM) and shows anti-tumor efficacy in U87MG glioblastoma and HCT116 colon carcinoma xenograft models in vivo (2.5 mg/kg bid. po.). |
|
|