| Identification | More | [Name]
4-PHENOXYBENZYLAMINE | [CAS]
107622-80-0 | [Synonyms]
4-PHENOXYBENZYLAMINE
(4-PHENOXYPHENYL)METHYLAMINE
AKOS B022085
ART-CHEM-BB B022085
RARECHEM AL BW 0345 | [Molecular Formula]
C13H13NO | [MDL Number]
MFCD01310836 | [Molecular Weight]
199.25 | [MOL File]
107622-80-0.mol |
| Chemical Properties | Back Directory | [Boiling point ]
138°C 5mm | [density ]
1,12 g/cm3 | [refractive index ]
1.59 | [Fp ]
150℃ | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in DMSO | [form ]
clear liquid | [pka]
9.13±0.10(Predicted) | [color ]
Colorless to Light orange to Yellow | [CAS DataBase Reference]
107622-80-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HazardClass ]
IRRITANT, IRRITANT-HARMFUL | [HS Code ]
2922290090 |
| Hazard Information | Back Directory | [Uses]
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against FL NS3/4a. | [Biological Activity]
4-Phenoxybenzylamine inhibits the function of NS3 protein by stabilizing the inactive conformation, and inhibits FL NS3/4a with an IC50 value of approximately 500 μM. | [in vitro]
A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation and thus represents a new class of direct acting antiviral agents. | [target]
| [References]
[1] Saalau-Bethell SM, et al. Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function. Nat Chem Biol. 2012 Nov;8(11):920-5. DOI:10.1038/nchembio.1081 |
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