| Identification | More | [Name]
Tosufloxacin tosilate | [CAS]
107097-79-0 | [Synonyms]
TOSUFLOXACIN TOSILATE
TOSUFLOXACIN TOSYLATE
7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid 4-methylbenzenesulfonate hydrate | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C26H23F3N4O6S | [MDL Number]
MFCD01711971 | [Molecular Weight]
576.54 | [MOL File]
107097-79-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
approximate 254℃ (dec.) | [InChI]
InChI=1S/C19H15F3N4O3.H2O/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25;/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29);1H2 | [InChIKey]
FCHGAGZTPICOSW-UHFFFAOYSA-N | [SMILES]
O=C1C(=CN(C2C=CC(F)=CC=2F)C2=NC(N3CCC(N)C3)=C(F)C=C12)C(=O)O.O | [CAS DataBase Reference]
107097-79-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Tosufloxacin (A-61827) tosylate is an orally active fluoroquinolone antibiotic. Tosufloxacin tosylate shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2]. | [Definition]
ChEBI: Tosufloxacin tosylate hydrate is a racemate comprising equimolar amounts of (R)- and (S)-tosufloxacin tosylate hydrate. It has a role as an antimicrobial agent, an antiinfective agent, a DNA synthesis inhibitor, a hepatotoxic agent and a topoisomerase IV inhibitor. It contains a (S)-tosufloxacin tosylate hydrate, a (R)-tosufloxacin tosylate hydrate and a tosufloxacin tosylate. | [Brand name]
Tosufloxacin Tosilate is JAN. | [References]
[1] Chu DT, et al. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs Exp Clin Res. 1990;16(9):435-43. PMID:2100244
[2] Fujimaki K, et al. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827-33. DOI:10.1128/AAC.32.6.827 |
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