| Identification | Back Directory | [Name]
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid | [CAS]
103878-83-7 | [Synonyms]
TeMpiuM
Ro 19-6327/001
JMFKTFLARGGXCC-UHFFFAOYSA-N
N-(2-Aminoethyl)-5-chlor-2-pyridincarbox
N-(2-Aminoethyl)-5-chlor-2-pyridincarboxamid-hydrochlorid
N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
2-PyridinecarboxaMide, N-(2-aMinoethyl)-5-chloro-, Monohydrochloride | [Molecular Formula]
C8H10ClN3O.HCl | [MOL File]
103878-83-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
193-195° | [storage temp. ]
Desiccate at RT | [solubility ]
Soluble to 100 mM in water and to 100 mM in DMSO | [form ]
Powder | [pka]
8.9(at 25℃) |
| Hazard Information | Back Directory | [Uses]
Treatment of Alzheimer’s disease. | [Definition]
ChEBI: Lazabemide hydrochloride is a pyridinecarboxamide. | [Brand name]
Tempium (Hoffmann-LaRoche). | [Biological Activity]
Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively). | [storage]
Desiccate at RT |
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