| Identification | Back Directory | [Name]
JPH203 | [CAS]
1037592-40-7 | [Synonyms]
JPH203
CS-2494
KYT0353
KYT 0353
JPH203
(KYT-0353
KYT-0353;JPH-203;JPH 203
KYT-0353;KYT0353;KYT 0353;JPH-203;JPH 203
JPH-203; JPH 203; KYT-0353; KYT 0353; KYT0353.
O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine
L-Tyrosine, O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-
(S)-2-Amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid | [Molecular Formula]
C23H19Cl2N3O4 | [MDL Number]
MFCD30534398 | [MOL File]
1037592-40-7.mol | [Molecular Weight]
472.32 |
| Chemical Properties | Back Directory | [Melting point ]
191 - 193°C | [Boiling point ]
672.0±55.0 °C(Predicted) | [density ]
1.458±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMF (Slightly, Heated), DMSO (Slightly) | [form ]
Solid | [pka]
2.14±0.30(Predicted) | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Uses]
O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine is a L-type amino acid transporter 1 (LAT1) specific and potent inhibitor that suppresses proliferation in cancer cell lines. | [Biological Activity]
JPH203 (KYT-0353) selectively inhibits L-type amino acid transporter LAT1-dependent L-leucine uptake and growth in HT-29 and human LAT1-expressing S2 murine renal proximal tubule cell culturesbut not human LAT2-expressing S2 cells (IC50/GI50 = 0.06/4.10.14/16.4and >10/>1000 μMrespectively). When administered via intravenous injection (6.3-25 mg/kg/d from d0 to d13)JPH203 effectively inhibits HT-29-derived tumor growth in mice in vivo. |
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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