| Identification | Back Directory | [Name]
GYKI 52466 HYDROCHLORIDE | [CAS]
102771-26-6 | [Synonyms]
466
2466
CS-813
GYKI-5
GYKI52
GYKI 52
Gyki Hcl
gyki52466
GYKI52466HCl
Gyki Hydrochloride
GYKI52466;GYKI-52466
GYKI 52466 HYDROCHLORIDE
GYKI 52466 dihydrochloride
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-5-yl)aniline
4-(8-Methyl-9H-1,3-dioxolo(4,5-H)(2,3)benzodiazepin-5-yl)benzenamine
1-(4-Aminophenyl)-4-methyl-7,8-(methylenedioxy)-5H-2,3-benzodiazepine
Benzenamine, 4-(8-methyl-9H-1,3-dioxolo(4,5-H)(2,3)benzodiazepin-5-yl)-
1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
4-(8-METHYL-9H-1,3-DIOXOLO[4,5-H][2,3]BENZODIAZEPIN-5-YL)-BENZENAMINE HYDROCHLORIDE
4-(8-Methyl-(9H)-1,3-dioxolo[4.5-h][2.3]benzodiazepine-5-yl)benzenaminehydrochloride
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenaminedihydrochloride
4-(8-methyl-8,9-dihydro-7H-[1,3]dioxolo[4,,5,:4,5]benzo[1,2-d][1,2]diazepin-5-yl)aniline | [Molecular Formula]
C17H16ClN3O2 | [MDL Number]
MFCD00885518 | [MOL File]
102771-26-6.mol | [Molecular Weight]
329.78 |
| Chemical Properties | Back Directory | [Boiling point ]
472.8±45.0 °C(Predicted) | [density ]
1.39 | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: 0.39 mg/mL | [form ]
solid | [pka]
8.14±0.20(Predicted) | [color ]
yellow |
| Hazard Information | Back Directory | [Uses]
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment. | [Uses]
4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)benzenamine is a non-competitive AMPA receptor antagonist and was found to have therapeutic potential for cocaine addiction treatment.
| [Definition]
ChEBI: GYKI 52466 is a benzodiazepine. | [Biological Activity]
Selective non-competitive AMPA receptor antagonist (IC 50 values are 10-20, ~ 450 and >> 50 μ M for AMPA- , kainate- and NMDA-induced responses respectively). Skeletal muscle relaxant and orally-active anticonvulsant. Has anti-proliferative effects in transformed cells. Also available as part of the AMPA Receptor Tocriset™ . Also available as part of the Kainate Receptor Tocriset™ . | [storage]
room temperature (desiccate) |
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