| Identification | Back Directory | [Name]
CALYCULIN A | [CAS]
101932-71-2 | [Synonyms]
C05370
CALYCULIN A
(-)-CALYCULIN A
Calyculin A
((-)-Calyculin A)
CALYCULIN A, DISCODERMIA CALYX
calyculin A from discodermia calyx
CALYCULIN A FROM DISCODERMIA CALYX, 10 U G
Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
InSolution Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem
N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentam
N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-Methoxy-4,6,8,9,13-pentaMethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-triMethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-o
L-Ribonamide, N-(3S)-3-4-(1E)-3-(2R,3R,5R,7S,8S,9R)-2-(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro4.5dec-7-yl-1-propenyl-2-oxa
L-Ribonamide, N-[(3S)-3-[4-[(1E)-3-[(2R,3R,5R,7S,8S,9R)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraen-1-yl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propen-1-yl]-2-oxazolyl]butyl]-4-deoxy-4-(dimet...
N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide | [Molecular Formula]
C50H81N4O15P | [MDL Number]
MFCD06795864 | [MOL File]
101932-71-2.mol | [Molecular Weight]
1009.17 |
| Chemical Properties | Back Directory | [Melting point ]
247-249° | [alpha ]
D -60° (c = 0.1 in ethanol) | [density ]
1.25±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble
| [form ]
solid
| [pka]
1.81±0.10(Predicted) | [color ]
white
| [biological source]
sea sponge (Discodermia calyx) | [optical activity]
+59.815 (Ethanol) | [Water Solubility ]
Soluble in DMSO (50 mM), ethanol (1 mg/ml), methanol, acetone, acetonitrile, chloroform, methylene chloride, and benzene. Insoluble in water. | [Merck ]
13,1731 | [BRN ]
4903216 |
| Hazard Information | Back Directory | [Uses]
Inhibitor of phosphatases 1 and 2a. | [General Description]
Calyculin A is derived from the marine sponge Discodermia calyx. It corresponds to a molecular weight of 1008 Da. | [Biological Activity]
Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC 50 = 0.3-0.7 nM) and protein phosphatase 2A (IC 50 = 0.5-1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C. | [Biochem/physiol Actions]
Inhibitor of protein phosphatases types 1 and 2A; marine toxin, potent tumor promotor. | [storage]
Store at -20°C |
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