Z-LEU-NH2 synthesis
- Product Name:Z-LEU-NH2
- CAS Number:4801-79-0
- Molecular formula:C14H20N2O3
- Molecular Weight:264.32
Yield:4801-79-0 100%
Reaction Conditions:
with 4-methyl-morpholine;ammonia in tetrahydrofuran;ethyl acetate;
Steps:
173.a a)
a) N-benzyloxycarbonyl-L-leucinamide To a stirring solution of N-benzyloxycarbonyl-L-leucine (4.6 g, 17.3 mmol) in THF, cooled to -40° C., was added N-methylmorpholine (3.68 g, 36.4 mmol; 4.0 mL) and isobutyl chloroformate (2.37 g, 17.3 mmol; 2.25 mL). After stirring for 15 min, ammonia was bubbled through the solution for 5 min. The solution was warmed to room temperature, evaporated, and the residue was dissolved in ethyl acetate, washed with 0.1 N Hcl, and saturated brine, then dried (MgSO4), filtered and evaporated to dryness to give the title compound as a white solid (4.58 g, 100%).
References:
US2002/49316,2002,A1
2018-66-8
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![L-Leucine, N-[N-[N-[N-[N-[N-[N-[(phenylmethoxy)carbonyl]-L-leucyl]-L-seryl]-L-seryl]-L-leucyl]-L-leucyl]-L-seryl]-, methyl ester](/CAS/20210305/GIF/158011-13-3.gif)
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4801-79-0
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