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ChemicalBook CAS DataBase List XPhos Pd G1
1028206-56-5

XPhos Pd G1 synthesis

1synthesis methods
XPhos Pd G1 is an insoluble solid that can be prepared by cross-coupling reactions of imidazole derivatives with dioxane. 
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Yield:1028206-56-5 70%

Reaction Conditions:

in further solvent(s);treatment of palladium compd. with methyllithium in methyl tert-butyl ether at 0°C, treatment with chlorobenzene deriv. and phosphine deriv. in methyl tert-butyl ether at 55°C; recrystn.;

References:

Biscoe, Mark R.;Fors, Brett P.;Buchwald, Stephen L. [Journal of the American Chemical Society,2008,vol. 130,# 21,p. 6686 - 6687]

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