Darunavir ethanolate synthesis
- Product Name:Darunavir ethanolate
- CAS Number:635728-49-3
- Molecular formula:C29H43N3O8S
- Molecular Weight:593.74
![tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate](/CAS/GIF/191226-98-9.gif)
191226-98-9
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: hydrogen; triethanolamine / palladium 10% on activated carbon / methanol / 2 h / 40 - 45 °C
2.1: hydrogenchloride; water / 2 h / Reflux
3.1: 1-methyl-pyrrolidin-2-one / 10 h / -4 - 30 °C
3.2: 1 h / 45 - 50 °C
References:
US2012/251826,2012,A1
![tert-Butyl [(1S,2R)-1-Benzyl-2-hydroxy-3-(isobutylamino)propyl]carbamate](/CAS/GIF/160232-08-6.gif)
160232-08-6
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$26.00/100mg
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![[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-[(4-aminophenyl)sulfonyl]amino] propyl]-carbamic Acid tert-Butyl Ester](/CAS/GIF/183004-94-6.gif)
183004-94-6
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$90.00/10mg
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98760-08-8
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$10.00/1g
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![4-AMINO-N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-N-ISOBUTYLBENZENE-1-SULFONAMIDE](/CAS/GIF/169280-56-2.gif)
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