Trospectomycin synthesis
- Product Name:Trospectomycin
- CAS Number:88669-04-9
- Molecular formula:C17H30N2O7
- Molecular Weight:374.43
![Carbamic acid, [7,9-bis(formyloxy)decahydro-4a-hydroxy-2-methyl-4-oxo-2H-pyrano[2,3-b][1,4]benzodioxin-6,8-diyl]bis[methyl-, bis(phenylmethyl) ester, [2R-(2α,4aβ,5aβ,6β,7β,8β,9α,9aα,10aβ)]- (9CI)](/CAS/20210305/GIF/88625-83-6.gif)
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Yield:-
Steps:
Multi-step reaction with 7 steps
1: 77 percent / pyridine, dimethylaminopyridine / ethyl acetate / 10 h / 55 °C
2: 1,3-dibromo-5,5-dimethyl hydantoin / CCl4 / 0.33 h / Ambient temperature; Irradiation
3: dimethylformamide / 8 h / 55 °C
4: hexamethyldisilazane / 2.5 h / 55 °C
5: 0 - 25 °C
6: 48percent aqueous HF / acetonitrile / 5 h / 0 °C
7: 59 percent / H2, pyridine / Pd/BaSO4 / propan-2-ol / 2.3 h / 760 Torr
References:
White, David R.;Cain, Gary A. [Tetrahedron Letters,1989,vol. 30,# 12,p. 1469 - 1472]
![Carbamic acid, [2-(1-butenyl)-4a,5a,6,7,8,9,9a,10a-octahydro-4a,7,9-trihydroxy-4-oxo-4H-pyrano[2,3-b][1,4]benzodioxin-6,8-diyl]bis[methyl-, bis(phenylmethyl) ester, [4aR-(4aα,5aα,6α,7α,8α,9β,9aβ,10aα)]- (9CI)](/CAS/20210305/GIF/103198-47-6.gif)
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![Carbamic acid, [(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-decahydro-4a,7,9-trihydroxy-2-methyl-4-oxo-2H-pyrano[2,3-b][1,4]benzodioxin-6,8-diyl]bis[N-methyl-, C,C'-bis(phenylmethyl) ester](/CAS/20211123/GIF/56733-83-6.gif)
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