Tris(4-cyanophenyl)methanol synthesis
1synthesis methods
- Product Name:Tris(4-cyanophenyl)methanol
- CAS Number:117678-98-5
- Molecular formula:C22H13N3O
- Molecular Weight:335.36
Yield:117678-98-5 64.7%
Reaction Conditions:
Stage #1: 4-bromobenzenecarbonitrilewith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;Inert atmosphere;
Stage #2: 4-cyanobenzoic acid methyl ester in tetrahydrofuran;hexane at 20;Inert atmosphere;
References:
Hu, Lianrui;Lam, Jacky W. Y.;Li, Xingguang;Liu, Junkai;Sung, Herman H. Y.;Tang, Ben Zhong;Wang, Haoran;Wang, Zhaoyu;Williams, Ian D.;Zeng, Zebing;Zhang, Haoke;Zhang, Jianyu;Zhang, Kaihua [Journal of the American Chemical Society,2021,vol. 143,# 25,p. 9565 - 9574] Location in patent:supporting information