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ChemicalBook CAS DataBase List TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE
817-09-4

TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE synthesis

3synthesis methods
-

Yield:817-09-4 100%

Reaction Conditions:

with thionyl chloride in 1,2-dichloro-ethane for 4 h;Reflux;

Steps:

2
Into a 1 L flask, equipped with a refluxing condenser, is added 29.8 g (0.20 mole) of triethanolamine, 300 mL of dichloroethane, then 51.0 mL of thionyl chloride. The mixture is heated to reflux for 4 hrs. The reaction is quenched by adding 20 mL of methanol. Removal of solvent gives a white crystalline mass of tris(2-chloroethylamine) hydrochloride in quantitative yield.

References:

Hu, Songzhou US2015/299113, 2015, A1 Location in patent:Paragraph 0050

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