ChemicalBook CAS DataBase List Trifluorothymine

Trifluorothymine synthesis

7synthesis methods

Product Name:Trifluorothymine
CAS Number:54-20-6
Molecular formula:C5H3F3N2O2
Molecular Weight:180.08

Uracil and sodium triflate can be used as raw materials to synthesize Trifluorothymine. This reaction uses a mixed solvent of methylene chloride and water as the reaction solvent and tert-butyl hydroperoxide as the catalyst.

2926-29-6 Synthesis

2926-29-6
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$6.00/5g

66-22-8 Synthesis

66-22-8
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$5.00/10g

54-20-6
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$6.00/250mg

Yield:54-20-6 91.9%

Reaction Conditions:

with sodium peroxodisulphate;copper(II) sulphate in lithium hydroxide monohydrate at 60 - 65; for 6 h;Temperature;Reagent/catalyst;

Steps:

1-8 Example 1

With a thermometer,11.2 g of uracil (0.1 mol) was added to the reaction vessel of the stirrer.23.4 g of sodium trifluoromethylsulfinate (0.15 mol), dissolved in 150 ml of water,Raise the temperature to 60 ° C, control the reaction temperature at 60 ~ 65 ° C,Add 50 grams of sodium persulfate and 5 grams in batchesThrough a mixture of copper sulfate,After reacting for 6 hours, after evaporating 100 ml of water,It was cooled and precipitated, and dried by filtration to obtain 14.7 g of 5-trifluoromethyluracil (I). HPLC was more than 99%.The yield was 91.9%.

References:

CN108503592,2018,A Location in patent:Page/Page column 3-6