ChemicalBook CAS DataBase List Triamcinolone acetonide

Triamcinolone acetonide synthesis

10synthesis methods

Product Name:Triamcinolone acetonide
CAS Number:76-25-5
Molecular formula:C24H31FO6
Molecular Weight:434.5

124-94-7 Synthesis

124-94-7
287 suppliers
$22.00/50mg

67-64-1
6 suppliers
$17.30/10ml

76-25-5
578 suppliers
$25.00/100mg

Yield:76-25-5 93%

Reaction Conditions:

with boron trifluoride diethyl etherate at -10 - 0;

Steps:

2 Preparation of triamcinolone acetonide
Triamcinolone (II-2)(Purchased from Sinopharm Group Chemical Reagent Co., Ltd.) (8g, 20mmol)With acetone(III-2) (400 ml)Keep the temperature from -10 ° C to 0 ° CBetween slowly adding46.5% boron trifluoride etherSolution(2 ml),25 ° C overnight, stirring with saturated sodium bicarbonate solution (10ml),The reaction solution was concentrated to about 50 ml, and the solid precipitated by filtration, washed with water and dried to obtain 8.2 g of triamcinolone acetonide,Yield: 93%,

References:

Shanghai Specialization Pharmaceutical Technology Co., Ltd.;Shandong Tefaman Pharmaceutical Co., Ltd.;Wu Mingjun;Chen Weiming;Zhu Fuqiang CN103421075, 2017, B Location in patent:Paragraph 0034-0036

FullText

3870-07-3 Synthesis