SODIUM FLUOROACETATE synthesis
- Product Name:SODIUM FLUOROACETATE
- CAS Number:62-74-8
- Molecular formula:C2H2FNaO2
- Molecular Weight:100.02
459-72-3
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62-74-8
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Yield:62-74-8 99%
Reaction Conditions:
with sodium hydroxide in ethanol at 0;
Steps:
28.A Step A: Sodium 2-fluoroacetate (28-b)
Ethyl 2-fluoroacetate, 28-a, (107g, lmol) was dissolved in absolute EtOH (1L), cooled to 0°C and NaOH (40g, lmol) in EtOH was added. The reaction was stirred overnight after which petroleum ether was added. The reaction solution was cooled to -20°C and filtered giving 104g of title compound, 28-b, as white solid (yield 99 %)
References:
MERCK SHARP & DOHME CORP.;ZHOU, Changyou;ZOU, Wuxin;HUA, Yuxia;DANG, Qun WO2013/40790, 2013, A1 Location in patent:Page/Page column 87
453-18-9
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62-74-8
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$50.00/25mg
51-21-8
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50-00-0
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$10.00/25g
62-74-8
1 suppliers
$50.00/25mg
57-13-6
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