ChemicalBook CAS DataBase List Tandospirone citrate

Tandospirone citrate synthesis

4synthesis methods

Product Name:Tandospirone citrate
CAS Number:112457-95-1
Molecular formula:C21H29N5O2.C6H8O7
Molecular Weight:575.615

87760-53-0 Synthesis

87760-53-0
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77-92-9 Synthesis

77-92-9
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$5.00/10g

112457-95-1
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Yield:112457-95-1 99%

Reaction Conditions:

in diethyl ether;acetone;Heating;

Steps:

1 Example 1 Preparation of crystalline form IV of tandospirone citrate

A solution of citric acid in acetone was prepared by dissolving 41 g of citric acid in 300 mL of acetone.Weigh 80gTandospirone,Join600 mL of acetone and 300 mL of ether,Dissolved,Dropping the configured citric acid acetone solution,Heating and stirring to complete the reaction,Natural cooling to room temperature for 6h,Filtration,washing,Dried under reduced pressure,That is 118. 8gWhite powder of tandospirone citrateForm IV,The yield was 99.0%.

References:

CN105985327,2016,A Location in patent:Paragraph 0035; 0036; 0037; 0038; 0039

20980-22-7 Synthesis