Sildenafil Impurity 13 synthesis
- Product Name:Sildenafil Impurity 13
- CAS Number:76424-56-1
- Molecular formula:C7H12N4O
- Molecular Weight:168.2
139756-08-4
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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76424-56-1
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$201.00/5mg
Yield: 36%
Reaction Conditions:
with sodium borohydrid;palladium in methanol;water
Steps:
37 4-Amino-3-n-propylpyrazole-5-carboxamide
EXAMPLE 37 4-Amino-3-n-propylpyrazole-5-carboxamide A solution of 4-nitro-3-n-propylpyrazole-5-carboxamide (198 mg, 1.0 mmol) in methanol (5 ml) was added dropwise to a mixture of sodium borohydride (113 mg, 2.97 mmol), 10% palladium on carbon (5 mg) and water (3 ml). The mixture was stirred at room temperature for 3 hours, filtered and the solvent removed by evaporation under vacuum. Crystallisation of the residue from ethyl acetate-methanol gave the title compound as an off-white solid (61 mg, 36%), m.p. 196°-201° C. Rf 0.4 (silica; dichloromethane, methanol, ammonium hydroxide; 90:10:1). Found: C,48.96; H,6.98; N,32.08. C7 H12 N4 O requires C,49.98; H,7.19; N,33.31%.
References:
Pfizer Inc. US5250534, 1993, A
139756-08-4
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76424-56-1
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$201.00/5mg
76424-47-0
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$14.00/100mg
76424-56-1
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76424-48-1
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76424-56-1
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$201.00/5mg
36983-31-0
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$9.00/250mg
76424-56-1
18 suppliers
$201.00/5mg