ChemicalBook CAS DataBase List SELENO-DL-METHIONINE

SELENO-DL-METHIONINE synthesis

11synthesis methods

Product Name:SELENO-DL-METHIONINE
CAS Number:2578-28-1
Molecular formula:C5H11NO2Se
Molecular Weight:196.11

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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2578-28-1
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Yield: 86.17%

Reaction Conditions:

with hydrogen bromide in tetrahydrofuran;1,4-dioxaneGreen chemistry;

Steps:

3.3; 4.3 Preparation of L-selenomethionine, the structural formula is as follows:
14.64g of N- Carbobenzyloxy L-selenomethionine was heated and stirred, then dropwise added 50mL of 10% HBr in 1,4-dioxane solution, after the reaction was completed, cooled to room temperature, and filtered to obtain a solid; The solid was added with 40 mL of H2O for dissolving, 2.11 g of lithium hydroxide monohydrate was added to the mixture, stirred at room temperature, then stirred with EtOH for 10 min. suction-filtered to obtain a solid which was washed with a mixture of ethanol and water, filtered, dried, and weighed to give a white solid 8.38g, total yield was 86.17%, and the HPLC content was 97.63%.

References:

Suzhou Zhishan Chemical Co., Ltd.;Xie Yineng;Wei Kaiju;Cui Yang CN108794365, 2018, A Location in patent:Paragraph 0022; 0026-0028; 0032; 0033