ChemicalBook CAS DataBase List SEC-BUTYLAMINE

SEC-BUTYLAMINE synthesis

7synthesis methods

Product Name:SEC-BUTYLAMINE
CAS Number:33966-50-6
Molecular formula:C4H11N
Molecular Weight:73.14

Sec-butylamine is prepared by reacting methyl ethyl ketone with ammonia Catalyzed by Raney nickel.

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109-73-9 Synthesis

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Yield:-

Reaction Conditions:

in ethyl acetate;N,N-dimethyl-formamide

Steps:

1.1 Step 1:
Step 1: 2-(N-benzoyl-N-butyl)amino-5-nitro-6-cyanopyridine To a solution of 3.0 g (16 mmol) of 2-chloro-5-nitro-6-cyano-pyridine in 10ml of dry DMF was added at 0° C. 2.18 g (21.6 mmol) of triethylaminefollowed by 1.4 g (18 mmol) of n-butyl amine. The reaction mixture was stirred for 5 hours, diluted with 100 ml of EtOAc and washed with water (3*10 ml). The aqueous phase was extracted with EtOAc (2*10 ml). The combined organic phases were washed with brine (1*30 ml) and dried over MgSO₄. The solution was filtered and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography over silica gel eluding with 80% CH₂ Cl₂ /hexanes to give 2.43 gof the intermediate 2-butyl amine.

References:

Merck & Co., Inc. US5330987, 1994, A