ChemicalBook CAS DataBase List S-NITROSOGLUTATHIONE

S-NITROSOGLUTATHIONE synthesis

10synthesis methods

Product Name:S-NITROSOGLUTATHIONE
CAS Number:57564-91-7
Molecular formula:C10H16N4O7S
Molecular Weight:336.32

70-18-8 Synthesis

70-18-8
985 suppliers
$6.00/1g

57564-91-7
160 suppliers
$18.00/5mg

Yield:57564-91-7 98%

Reaction Conditions:

with diethylenetriaminopentaacetic acid;L-phenylalanine;1-nitrosopyrrolidine-2-thiocarboxamide; pH=1.5 at 37;Darkness;Reagent/catalyst;

Steps:

5.4.2 Reaction of 2, 3, or 4 with GSH
General procedure: Aliquots of l-phenylalanine (300 μL, 4.5 mM), GSH (300 μL, 5.0 mM), and DTPA (150 μL, 1.2 μM) were mixed, and the pH was adjusted to 1.5 with 0.1 M HCl for a total volume of 2.7 mL. The reaction was initiated by adding 2-4 (300 μL, 0.45 mM) at 37 °C. Aliquots were collected at specified intervals, and the GSNO yield was determined via HPLC using a Shiseido UG120 (5 μm, 250×4.6 mm) column with acetonitrile/0.05 % trifluoroacetic acid (7:93) as the eluent at 1.0mL/min for 2 and methanol/0.05 % trifluoroacetic acid (5:95) as the eluent at 1.0mL/min for 3 and 4 at 335 nm.

References:

Inami, Keiko;Kondo, Sonoe;Ono, Yuta;Saso, Chiharu;Mochizuki, Masataka [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 24,p. 7853 - 7857]

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70-18-8 Synthesis

70-18-8
985 suppliers
$6.00/1g