ChemicalBook CAS DataBase List (S)-(-)-N,N-DIMETHYL-1-FERROCENYLETHYLAMINE

(S)-(-)-N,N-DIMETHYL-1-FERROCENYLETHYLAMINE synthesis

3synthesis methods

Product Name:(S)-(-)-N,N-DIMETHYL-1-FERROCENYLETHYLAMINE
CAS Number:31886-57-4
Molecular formula:C14H19FeN10*
Molecular Weight:257.15

1277-49-2
150 suppliers
$10.00/250mg

124-40-3
520 suppliers
$18.00/100ml

(S)-(-)-N,N-DIMETHYL-1-FERROCENYLETHYLAMINE

31886-57-4
127 suppliers
$10.00/100mg

Yield:31886-57-4 89%

Reaction Conditions:

Stage #1: 1-ferrocenylethanolwith acetic anhydride;triethylamine in dichloromethane at 20; for 3 h;Large scale;
Stage #2: dimethyl amine in dichloromethane;water; for 5 h;Large scale;Temperature;Solvent;

Steps:

5.3

(3) (S)-1-ferrocenylethanol 2 (1.03 kg, 4.47 mol) prepared above, dichloromethane (3.0 L),Triethylamine (902.9 g, 8.94 mol) was placed in the reaction vessel in turn, acetic anhydride (683.4 g, 6.70 mol) was added dropwise at room temperature, and the reaction was stirred for 3 h;Then slowly add 4.31kg of 33% dimethylamine aqueous solution, continue stirring for 5h; static layering, concentration and concentration to recover dichlorohexane.The residue was distilled under reduced pressure to collect a fraction of 110 ° C (0.07 kPa) to obtain (S)-N,N-Dimethyl-1-ferrocenylethylamine 3 (1.02 kg).Dark red oily liquid, yield: 89%; HPLC purity: 98%; ee: 96%.

References:

CN108409802,2018,A Location in patent:Paragraph 0050; 0053

102-54-5 Synthesis